Tetanus as a cause of acute renal failure: possible role of rhabdomyolysis

• Published in: Revista da Sociedade Brasileira de Medicina Tropical Vol. 26; no. 1; pp. 1 - 4
• Main Authors: Martinelli, R, Matos, C M, Rocha, H
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Sociedade Brasileira de Medicina Tropical 1993; Sociedade Brasileira de Medicina Tropical - SBMT; Sociedade Brasileira de Medicina Tropical (SBMT)
• Subjects: Acute Kidney Injury - etiology; Acute renal failure; Adult; Female; Humans; Insuficiência renal aguda; Male; Mioglobina; Myoglobin; Rabdomiólise; Rhabdomyolysis; Rhabdomyolysis - complications; Tetanus; Tetanus - complications; TROPICAL MEDICINE; Tétano; Myoglobin; Tétano; Mioglobina; Rabdomiólise; Insuficiência renal aguda; Tetanus; Rhabdomyolysis; Acute renal failure
• ISSN: 0037-8682; 1678-9849; 0037-8682; 1678-9849
• DOI: 10.1590/S0037-86821993000100001

To study the frequency and examine the role of rhabdomyolysis in the acute renal failure in tetanus 18 patients with the diagnosis of generalized tetanus consecutively admitted to the infectious disease hospital were evaluated. Of these 14 were male and 4 female with mean age of 31.8 +/- 2.0 years. Except for mild proteinuria recorded in 9 patients, the urinalysis were unremarkable. Serum creatinine higher than 1.4mg/dl was recorded in 39% of the patients, abnormal levels of CPK in 87,5% and serum myoglobin greater than 120 micrograms/l in 39% of the patients. Oliguria was documented in one patient and none required dialysis therapy. No correlation was found between renal failure and myoglobin and/or CPK serum levels. Acute renal failure in tetanus was not infrequent; usually it was non-oliguric, mild and transient and not related to the severity of the disease or to serum levels of myoglobin and/or CPK.