Optically active titanium complexes containing a tridentate linked amido-cyclopentadienyl ligand

• Published in: Chirality (New York, N.Y.) Vol. 12; no. 5-6; pp. 472 - 475
• Main Authors: Okuda, Jun, Verch, Sabine, Stürmer, Rainer, Spaniol, Thomas P.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 2000
• Subjects: amido-cyclopentadienyl ligand; chiral amine; imine hydrogenation catalyst; titanium catalysts
• ISSN: 0899-0042; 1520-636X
• DOI: 10.1002/(SICI)1520-636X(2000)12:5/6<472::AID-CHIR30>3.0.CO;2-Q

Optically active titanium complexes Ti{η5:η1‐C5R4SiMe2NC6H10 (OCH2Ph)‐2}Cl2 (R = H, Me), containing a cyclopentadienyl ligand linked to the chiral trans‐2‐benzyloxycyclohexylamido group, were synthesized and characterized in both enantiomerically pure forms. A single crystal X‐ray structure analysis of (−)‐(R,R)‐Ti{η5:η1‐C5H4SiMe2NC6H10(OCH2Ph)‐2}Cl2 shows a structure in which the benzyloxy group in the amido sidechain is not interacting with the titanium center. Upon activation with n‐butyllithium, these complexes hydrogenate acetophenone N‐benzylimine with low enantioselectivity. Chirality 12:472–475, 2000. © 2000 Wiley‐Liss, Inc.