A Novel Feature-Map Based ICA Model for Identifying the Individual, Intra/Inter-Group Brain Networks across Multiple fMRI Datasets

• Published in: Frontiers in neuroscience Vol. 11; p. 510
• Main Authors: Wang, Nizhuan, Chang, Chunqi, Zeng, Weiming, Shi, Yuhu, Yan, Hongjie
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 08.09.2017; Frontiers Media S.A
• Subjects: big neuroimaging data; Brain mapping; Clustering; Data analysis; Datasets; Dictionaries; feature maps; fMRI; Functional magnetic resonance imaging; ICA; intragroup analysis; Medical imaging; Methods; Nervous system; Neural networks; Neuroimaging; Neuroscience; NMR; Nuclear magnetic resonance; Studies; subject-specific analysis; China; fMRI; subject-specific analysis; intergroup analysis; ICA; feature maps; big neuroimaging data; intragroup analysis
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2017.00510

Independent component analysis (ICA) has been widely used in functional magnetic resonance imaging (fMRI) data analysis to evaluate functional connectivity of the brain; however, there are still some limitations on ICA simultaneously handling neuroimaging datasets with diverse acquisition parameters, e.g., different repetition time, different scanner, etc. Therefore, it is difficult for the traditional ICA framework to effectively handle ever-increasingly big neuroimaging datasets. In this research, a novel feature-map based ICA framework (FMICA) was proposed to address the aforementioned deficiencies, which aimed at exploring brain functional networks (BFNs) at different scales, e.g., the first level (individual subject level), second level (intragroup level of subjects within a certain dataset) and third level (intergroup level of subjects across different datasets), based only on the feature maps extracted from the fMRI datasets. The FMICA was presented as a hierarchical framework, which effectively made ICA and constrained ICA as a whole to identify the BFNs from the feature maps. The simulated and real experimental results demonstrated that FMICA had the excellent ability to identify the intergroup BFNs and to characterize subject-specific and group-specific difference of BFNs from the independent component feature maps, which sharply reduced the size of fMRI datasets. Compared with traditional ICAs, FMICA as a more generalized framework could efficiently and simultaneously identify the variant BFNs at the subject-specific, intragroup, intragroup-specific and intergroup levels, implying that FMICA was able to handle big neuroimaging datasets in neuroscience research.