An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition

An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4‐Disubstituted quinazolines have been synthesized from three‐component one‐pot reactions of 2‐aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advan...

Full description

Saved in:
Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 52; no. 4; pp. 1253 - 1259
Main Authors Bhat, Subrahmanya Ishwar, Das, U. K., Trivedi, Darshak R.
Format Journal Article
LanguageEnglish
Published HOBOKEN Blackwell Publishing Ltd 01.07.2015
Wiley
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ANTIINFLAMMATORY EVALUATION
INHIBITORS
LIGAND
2-PHENYLQUINAZOLINES
DERIVATIVES
DISCOVERY
Online AccessGet full text

Cover

More Information
Summary:An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4‐Disubstituted quinazolines have been synthesized from three‐component one‐pot reactions of 2‐aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76–94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X‐ray analysis of isolated intermediate.
Bibliography:ArticleID:JHET2220
istex:584372316D1EFDE881CF6A46A5C7EAA4304C9D6F
ark:/67375/WNG-NTLPRBHT-B
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2220