DECREASED THRESHOLD FOR THE NITRIC OXIDE DONOR GLYCERYL TRINITRATE IN CORTISOL-INDUCED HYPERTENSION IN HUMANS

SUMMARY 1 Decreased nitric oxide (NO) availability is thought to be a feature of cortisol‐induced hypertension in humans. 2 We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3 We re‐analysed data from a study of baroreflex func...

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Bibliographic Details
Published inClinical and experimental pharmacology & physiology Vol. 34; no. 12; pp. 1317 - 1318
Main Authors Kelly, JJ, Tam, SH, Williamson, PM, Whitworth, JA
Format Journal Article
LanguageEnglish
Published Melbourne, Australia Blackwell Publishing Asia 01.12.2007
Subjects
Adult
blood pressure
Blood Pressure - drug effects
cortisol
glucocorticoids
glyceryl trinitrate
Humans
Hydrocortisone
Hypertension - chemically induced
Hypertension - drug therapy
Hypertension - physiopathology
Male
nitric oxide
Nitric Oxide - metabolism
Nitric Oxide Donors - therapeutic use
Nitroglycerin - therapeutic use
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Summary:SUMMARY 1 Decreased nitric oxide (NO) availability is thought to be a feature of cortisol‐induced hypertension in humans. 2 We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3 We re‐analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4 Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5 These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.
Bibliography:ArticleID:CEP4700
ark:/67375/WNG-T7B39PWW-T
istex:F16F0FB70E94E584829FC481D6D417256B6EF56B
ISSN:0305-1870
1440-1681
DOI:10.1111/j.1440-1681.2007.04700.x