Association of Plasma Cholesterol Profile in Sudanese Patients with Hypertension

• Published in: Annals of African medicine Vol. 24; no. 3; pp. 586 - 590
• Main Authors: Modawe, Gad Allah, Gesmalla, Ryan, Mirghani, Nada, Mutasem, Reham, Adnan, Fatima, Elseddig, Awatef, Emad, Roba, Mohieldein, Abdelmarouf
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.07.2025; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd
• Edition: 2
• Subjects: Adult; Aged; Analysis; Blood Pressure; Body mass index; Case-Control Studies; Cholesterol; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Female; High density lipoprotein; Humans; Hypertension; Hypertension - blood; Hypertension - epidemiology; Low density lipoproteins; Male; Medical research; Medicine, Experimental; Middle Aged; Mortality; Original; Original Article; Plasma; Risk Factors; Sudan; Sudan - epidemiology; Type 2 diabetes; Sudan; Sudanese; cholestérol total; low-density lipoprotein cholesterol; Cholestérol de lipoprotéines à haute densité; soudanais; High-density lipoprotein cholesterol; hypertension; total cholesterol; cholestérol lipoprotéine à basse densité
• ISSN: 1596-3519; 0975-5764; 0975-5764
• DOI: 10.4103/aam.aam_87_24

Context: Hypertension (HTN) is a common disease which ultimately leads to mortality from cardiovascular diseases (CVDs). Aims: This study aimed to assess the cholesterol profile among Sudanese patients with HTN in Khartoum State, Sudan. Subjects and Methods: A case-control study was conducted in Khartoum State from January 2023 to April 2023. A total of 100 subjects were enrolled in the study: 50 HTN patients as the case group and 50 normotensive individuals as the control group. The plasma cholesterol profile was measured using spectrophotometric methods. The data were analyzed using SPSS. Results: Plasma levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were significantly higher in patients compared to healthy controls (P = 0.000). In contrast, plasma level of high-density lipoprotein cholesterol (HDL-C) was significantly lower in patients than in the control group (P = 0.001). TC was significantly positively correlated with age, systolic blood pressure (SBP), and diastolic blood pressure (DBP) (P = 0.001, P = 0.000, and P = 0.000, respectively). Similarly, plasma LDL-C was significantly positively correlated with SBP, DBP, and age (P = 0.001, P = 0.001, and P = 0.001, respectively). Conversely, plasma HDL-C was significantly negatively correlated with SBP, DBP, age, and body mass index (BMI) (P = 0.000, P = 0.000, P = 0.007, and P = 0.006, respectively). Conclusions: Hypertensive patients showed significantly higher plasma TC and LDL-C but lower HDL-C compared to healthy controls. TC and LDL-C levels significantly positively correlated with age, SBP, and DBP, whereas HDL-C was significantly negatively correlated with SBP, DBP, age, and BMI. Cholesterol management in hypertensive patients reduces the risk for CVDs, a major concern for patients with HTN.