Relationship between lead absorption and iron status and its association with oxidative stress markers in lead-exposed workers

• Published in: Journal of trace elements in medicine and biology Vol. 68; p. 126841
• Main Authors: Słota, Michał, Wąsik, Marta, Stołtny, Tomasz, Machoń-Grecka, Anna, Kasperczyk, Aleksandra, Bellanti, Francesco, Dobrakowski, Michał, Chwalba, Artur, Kasperczyk, Sławomir
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.12.2021
• Subjects: Antioxidants; Biomarkers; Blood lead; Child; Humans; Iron; Iron Deficiencies; Iron status; Lead; Lead - metabolism; Lead exposure; Lead Poisoning; Male; Oxidative Stress; ROS; Lead; Oxidative stress; Blood lead; Lead exposure; Iron status; ROS
• ISSN: 0946-672X; 1878-3252
• DOI: 10.1016/j.jtemb.2021.126841

[Display omitted] •Study examined an association of iron level and lead toxicity in exposed population.•PCA analysis showed that high Fe subgroup had lower Zn protoporphyrin levels.•Higher Fe levels were also associated with an increased total antioxidant capacity.•Fe status may affect the severity of Pb poisoning and alleviate an oxidative stress. The emission of lead (Pb) occurring during the extraction, processing and industrial applications of this element remains a significant environmental risk factor. The absorbability of lead in humans is strongly associated with the general health status of exposed individuals. Existing mineral deficiencies are considered being a predisposition to an increased Pb uptake. Both, iron deficiency and lead poisoning are the major causative factors responsible for the prevalence of anemia within the vulnerable population, especially in children. Although some of the intervention programs of counteracting lead poisoning by iron supplementation proved to be effective in the Pb-exposed population, the exact mechanisms of this interaction still require further studies. The objective of the presented study was to examine the association of iron level on oxidative stress measures and its effects on the severity of lead toxicity in the exposed population. The analyzed population consisted of 270 male workers from the lead-zinc smelter. The studied population was divided into two sub-groups based on the serum iron concentration: low iron level group (L-Fe; Fe < median value) and high iron level group (H-Fe; Fe > median value). Measured traits comprised of blood lead (PbB), serum Fe and zinc protoporphyrin (ZPP) levels as well as a blood count and oxidative stress markers. No significant correlation between serum iron concentration and PbB in the tested cohort was found. On the contrary, the analysis of ZPP levels (long-term marker related to a hematologic toxic effect of Pb) within the subgroups differing in serum Fe level shown that ZPP was 12.3 % lower (p = 0.043) in subjects classified within the H-Fe group. A positive correlation of serum Fe and total antioxidant capacity (TAC) was found (R = 0.1999). The conducted 3-D PCA analysis showed that individuals classified within the H-Fe group were characterized by the co-occurrence of higher Fe levels, lower ZPP, and higher TAC value. These results support the existing evidence providing that maintaining the optimal status of Fe may play a significant role in preventing the lead poisoning and alleviating harmful effects of Pb on the oxidative balance in humans.