Mutagenic activity of surface waters adjacent to a nuclear fuel processing facility

Surface water samples were collected at 8 Nolichucky river basin sites upstream, downstream and immediately adjacent to a nuclear fuel processing facility. Organic extracts of the water samples were assayed using the Ames Salmonella mammalian microsome test. With one exception, all extracts were non...

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Published inArchives of environmental contamination and toxicology Vol. 16; no. 5; pp. 531 - 537
Main Authors PANCORBO, O. C, LEIN, P. J, BLEVINS, R. D
Format Journal Article
LanguageEnglish
Published Heidelberg Springer-Verlag 01.09.1987
Berlin
New York, NY
Subjects
Animals
Biological and medical sciences
Chemical mutagenesis
Freshwater
In Vitro Techniques
Medical sciences
Mutagenicity Tests
Mutagens
Nuclear Energy
Rats
Toxicology
Water Pollutants - toxicity
Water Pollutants, Radioactive - analysis
Water Pollutants, Radioactive - toxicity
Ames test
Mutagenicity testing
Bacteria
Nuclear fuel
Water pollution
Escherichieae
Salmonella typhimurium
Fuel processing
Enterobacteriaceae
Waste water
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Summary:Surface water samples were collected at 8 Nolichucky river basin sites upstream, downstream and immediately adjacent to a nuclear fuel processing facility. Organic extracts of the water samples were assayed using the Ames Salmonella mammalian microsome test. With one exception, all extracts were non-mutagenic with strains TA97, TA98, TA100, TA102 and TA1535, with and without metabolic response with TA102 in the presence of S-9, but not in its absence, and showed no mutagenic activity with any other strain. Banner creek received wastewater from the nuclear fuel processing plant, and tributylphosphate was identified (by GC-MS) as the major constituent in the mutagenic extract. However, tributylphosphate itself (9.8 ng-196 ug per plate) was not mutagenic, and it was suggested that the mutagenic response obtained with Banner creek water extracts might be due to radionuclides complexed to tributylphosphate.
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ISSN:0090-4341
1432-0703
DOI:10.1007/BF01055809