Association of base excision repair pathway genes OGG1, XRCC1 and MUTYH polymorphisms and the level of 8-oxo-guanine with increased risk of colorectal cancer occurrence

In this work authors investigate influence of selected polymorphisms of DNA repair genes (XRCC1, OGG1 and MUTYH) and level of oxidative damage (measured as level of 8-oxo-guanine, 8-oG) on modulation of the risk of colorectal cancer. The relationship between mutations in the DNA Mismatch Repair (MMR...

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Bibliographic Details
Published inInternational journal of occupational medicine and environmental health Vol. 35; no. 5; pp. 625 - 633
Main Authors Kabziński, Jacek, Majsterek, Ireneusz
Format Journal Article
LanguageEnglish
Published Heidelberg Nofer Institute of Occupational Medicine 01.01.2022
Subjects
Base excision repair
Cancer
Colorectal cancer
Colorectal carcinoma
Deoxyribonucleic acid
DNA
DNA repair
Gene polymorphism
Genes
Genotype & phenotype
Genotypes
Health risks
Lung cancer
Mismatch repair
Modulation
MSH2 protein
Mutation
mutyh
ogg1
OGG1 protein
Original Paper
Oxidative stress
Patients
Polymorphism
Risk levels
Variance analysis
xrcc1
XRCC1 protein
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Summary:In this work authors investigate influence of selected polymorphisms of DNA repair genes (XRCC1, OGG1 and MUTYH) and level of oxidative damage (measured as level of 8-oxo-guanine, 8-oG) on modulation of the risk of colorectal cancer. The relationship between mutations in the DNA Mismatch Repair (MMR) genes and the increased risk of hereditary nonpolyposis colorectal cancer (HNPCC) in which genetic changes within the MSH2 gene are observed in approx. 60% of patients [2,3], gave rise to search for a similar effect on CRC incidence in other types of DNA repair systems. The aim of this study was to investigate the effect of BER gene polymorphisms OGG1 Ser326Cys, XRCC1 Arg399Gln and MUTYH Gln324His on the modulation of CRC risk. [...]these data are supplemented with the levels of 8-oG broken down into each of the tested variants, in order to assess the possible impact of the effectiveness of antioxidant mechanisms on the risk level. [...]measurement of 8-oG levels in relation to specific genotypes showed that group with Ser/Cys genotype of the OGG1 gene had statistically significantly higher level than remaining 2 genotypes.
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ISSN:1232-1087
1896-494X
DOI:10.13075/ijomeh.1896.01901