Epilepsy surgery for low-grade epilepsy-associated neuroepithelial tumor of temporal lobe: a single-institution experience of 61 patients

• Published in: Neurological sciences Vol. 43; no. 5; pp. 3333 - 3341
• Main Authors: Zheng, Zhe, Jiang, Hongjie, Wu, Hemmings, Ding, Yao, Wang, Shuang, Ming, Wenjie, Zhu, Junming
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2022; Springer Nature B.V
• Subjects: Antiepileptic agents; Convulsions & seizures; Electroencephalography; Epilepsy; Epilepsy - etiology; Epilepsy - pathology; Epilepsy - surgery; Epilepsy, Temporal Lobe - pathology; Humans; Medicine; Medicine & Public Health; Neoplasms, Neuroepithelial - complications; Neoplasms, Neuroepithelial - surgery; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Original; Original Article; Patients; Psychiatry; Retrospective Studies; Seizures; Seizures - pathology; Surgery; Temporal lobe; Temporal Lobe - pathology; Temporal Lobe - surgery; Treatment Outcome; Tumors; Temporal lobe; Low-grade epilepsy-associated neuroepithelial tumor; Seizure; Extended resection; Electrocorticogram; Surgery
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-021-05703-3

Background Low-grade epilepsy-associated neuroepithelial tumor (LEAT) is highly responsive to surgery in general. The appropriate surgical strategy remains controversial in temporal LEAT. The aim of this study is to analyze the surgical seizure outcome of temporal LEAT, focusing on the aspects of surgical strategy. Methods Sixty-one patients from a single epilepsy center with temporal LEAT underwent surgery. The surgical strategy was according to the multidisciplinary presurgical evaluation. Electrocorticogram (ECoG)-assisted resection was utilized. Surgical extent including lesionectomy and extended resection was described in detail. Seizure outcome was classified as satisfactory (Engel class I) and unsatisfactory (Engel classes II–IV). Results After a median follow-up of 36.0 (30.0) months, 83.6% of patients achieved satisfactory outcome, including 72.1% with Engel class Ia. There was 39.3% (24/61) of patients with antiepileptic drug (AED) withdrawal. Use of ECoG (χ2 = 0.000, P  > 0.1), preresection spike (χ2 = 0.000, P  = 0.763), or spike residue ( P  = 0.545) was not correlated with the seizure outcome. For lateral temporal LEAT, outcome from lesionectomy was comparable to extended resection (χ2 = 0.499, P  > 0.1). For mesial temporal LEAT, 94.7% (18/19) of patients who underwent additional hippocampectomy were satisfactory, whereas only 25% (1/4) of patients who underwent lesionectomy were satisfactory ( P  = 0.009). Conclusion Surgical treatment was highly effective for temporal LEAT. ECoG may not influence the seizure outcome. For lateral temporal LEAT, lesionectomy with or without cortectomy was sufficient in most patients. For mesial temporal LEAT, extended resection was recommended.