Changes in serum and urinary amino acids after the administration of a mixed beta-adrenergic agonist

The administration of the repartitioning agent metaproterenol, with affinity for beta 1- and beta 2-receptors, induced marked increases in gastrocnemius muscle and heart weights. The renal loss of essential amino acids was reduced in animals treated with beta-adrenergic agonists and a significant re...

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Bibliographic Details
Published inAnnals of nutrition and metabolism Vol. 36; no. 5/6; pp. 328 - 335
Main Authors Martinez, J.A, Rguez-Mariscal, M, Del Barrio, A.S, Larralde, J
Format Journal Article
LanguageEnglish
Published Switzerland 1992
Subjects
amino acids
Amino Acids - blood
Amino Acids - urine
Animals
beta-adrenergic agonists
blood serum
Creatinine - urine
Heart - anatomy & histology
Hydroxyproline - urine
Male
Metaproterenol - pharmacology
Methylhistidines - urine
Muscles - anatomy & histology
Muscles - metabolism
nutrition physiology
Organ Size - drug effects
protein turnover
Rats
Rats, Wistar
Urea - urine
urine
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Summary:The administration of the repartitioning agent metaproterenol, with affinity for beta 1- and beta 2-receptors, induced marked increases in gastrocnemius muscle and heart weights. The renal loss of essential amino acids was reduced in animals treated with beta-adrenergic agonists and a significant reduction in total serum amino acids was found as well. The assessment of urinary 3-methylhistidine suggests, that those changes were accompanied by a lower myofibrillar protein breakdown, while hydroxyproline output was increased as an indirect index of collagen turnover.
ISSN:0250-6807
1421-9697
DOI:10.1159/000177737