Targeting the (Un)differentiated State of Cancer

Dedifferentation in cancer is associated with intrinsic and acquired resistance to therapies. In this issue of Cancer Cell, Tsoi et al. identify four differentiation states in melanoma and provide evidence that melanoma cells develop drug resistance through a stepwise dedifferentiation process, maki...

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Bibliographic Details
Published inCancer cell Vol. 33; no. 5; pp. 793 - 795
Main Authors Kemeny, Lajos V., Fisher, David E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 14.05.2018
Subjects
Cell Differentiation
Cell Line, Tumor
Humans
Iron
Melanoma
Oxidative Stress
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Summary:Dedifferentation in cancer is associated with intrinsic and acquired resistance to therapies. In this issue of Cancer Cell, Tsoi et al. identify four differentiation states in melanoma and provide evidence that melanoma cells develop drug resistance through a stepwise dedifferentiation process, making them vulnerable to ferroptotic cell death-inducing compounds. Dedifferentation in cancer is associated with intrinsic and acquired resistance to therapies. In this issue of Cancer Cell, Tsoi et al. identify four differentiation states in melanoma and provide evidence that melanoma cells develop drug resistance through a stepwise dedifferentiation process, making them vulnerable to ferroptotic cell death-inducing compounds.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2018.04.007