Influence of site of expression on the fetal gamma delta T-cell receptor repertoire

The sequences of productive T-cell gamma/delta receptor transcripts were compared in different murine fetal tissues. Differences from tissue to tissue suggest that the sequence repertoires are at least in part the products of selection, presumably through interaction of T cells bearing the gamma del...

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Bibliographic Details
Published inProceedings of the National Academy of Sciences - PNAS Vol. 88; no. 17; pp. 7830 - 7833
Main Authors Kyes, S, Pao, W, Hayday, A
Format Journal Article
LanguageEnglish
Published United States National Acad Sciences 01.09.1991
Subjects
Animals
Base Sequence
Fetus
Gene Expression
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Gene Rearrangement, T-Lymphocyte
Intestines - embryology
Intestines - immunology
Liver - embryology
Liver - immunology
Macromolecular Substances
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular Sequence Data
Multigene Family
Oligonucleotide Probes
Receptors, Antigen, T-Cell - genetics
Skin - embryology
Skin - immunology
Thymus Gland - embryology
Thymus Gland - immunology
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Summary:The sequences of productive T-cell gamma/delta receptor transcripts were compared in different murine fetal tissues. Differences from tissue to tissue suggest that the sequence repertoires are at least in part the products of selection, presumably through interaction of T cells bearing the gamma delta receptor with fetal self-ligands.
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ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.88.17.7830