Adaptive and Maladaptive Responses in Skin: Mild Heat Exposure Protects against UVB-induced Photoaging in Mice

In this issue, Matsuda et al. demonstrate the protective effect of mild heat preconditioning on UVB-induced photoaging in SKH-1 hairless mice. Mild heat exposure stimulates the upregulation of HSP70 chaperones, which inhibit the activities of matrix-degenerating enzymes, thereby avoiding wrinkle for...

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Bibliographic Details
Published inJournal of investigative dermatology Vol. 133; no. 4; pp. 868 - 871
Main Authors Haarmann-Stemmann, Thomas, Boege, Fritz, Krutmann, Jean
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2013
Elsevier Limited
Subjects
Animals
Heat-Shock Response - physiology
HSP70 Heat-Shock Proteins - genetics
Mice
Skin Aging - genetics
Skin Aging - radiation effects
Ultraviolet Rays - adverse effects
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Summary:In this issue, Matsuda et al. demonstrate the protective effect of mild heat preconditioning on UVB-induced photoaging in SKH-1 hairless mice. Mild heat exposure stimulates the upregulation of HSP70 chaperones, which inhibit the activities of matrix-degenerating enzymes, thereby avoiding wrinkle formation. This newly identified heat-mediated process of adaptation to UVB radiation exposure opens new opportunities to slow extrinsic skin aging.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Commentary-1
ISSN:0022-202X
1523-1747
DOI:10.1038/jid.2012.435