Erythroid cells in suppressing leukemia cell growth

This paper indicates that murine nucleated erythroid cells (EC) are able to reduce, in a dose-dependent manner, the proliferation of both L1210 lymphoma and P815 mastocytoma cells and that the leukemia cell growth inhibitory activity of unseparated bone marrow (BM) cells may be markedly augmented by...

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Published inLeukemia & lymphoma Vol. 46; no. 9; pp. 1353 - 1356
Main Authors Seledtsov, VI, Seledtsova, GV, Samarin, DM, Senyukov, VV, Poveschenko, OV, Felde, MA, Kozlov, VA
Format Journal Article
LanguageEnglish
Published United States Informa UK Ltd 01.09.2005
Taylor & Francis
Subjects
Animals
Bone Marrow Cells - physiology
Cell Division - drug effects
Cells, Cultured
Erythroid cell
Erythroid Cells - cytology
Erythropoietin - pharmacology
leukemia growth inhibition
Leukemia L1210 - pathology
Leukemia, Experimental - pathology
Leukemia, Experimental - prevention & control
Mice
Mice, Inbred Strains
Tumor Cells, Cultured
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Summary:This paper indicates that murine nucleated erythroid cells (EC) are able to reduce, in a dose-dependent manner, the proliferation of both L1210 lymphoma and P815 mastocytoma cells and that the leukemia cell growth inhibitory activity of unseparated bone marrow (BM) cells may be markedly augmented by their short-term culturing with erythropoietin (Epo). These results raise the intriguing possibility to utilize erythropoesis-stimulating, therapeutic strategies with the purpose of inhibiting leukemia cell growth in the body.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190500160207