Vascular endothelium as a target tissue for short-term exposure to low-frequency noise that increases cutaneous blood flow

• Published in: The Science of the total environment Vol. 851; no. Pt 1; p. 158828
• Main Authors: Deng, Yuqi, Ohgami, Nobutaka, Kagawa, Takumi, Kurniasari, Fitri, Chen, Dijie, Kato, Masashi, Tazaki, Akira, Aoki, Masayo, Katsuta, Hiroki, Tong, Keming, Gu, Yishuo
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 10.12.2022
• Subjects: Cutaneous blood flow; Endothelium; Low-frequency noise; Nitric oxide; Target tissue; Low-frequency noise; Cutaneous blood flow; Target tissue; Nitric oxide; Endothelium
• ISSN: 0048-9697; 1879-1026; 1879-1026
• DOI: 10.1016/j.scitotenv.2022.158828

Harmful health effects of exposure to low-frequency noise (LFN) defined as noise with frequencies at ≤100 Hz on the circulatory system have been a concern. However, there has been no study on the effects of exposure to LFN on the circulatory system with consideration of its frequencies and decibels. In this study, the effects of short-term exposure to broad-band LFNs and their pure-tone components (pure-tone LFNs) on cutaneous blood flow in the extremities including the hands were investigated. In our fieldwork study, we first sampled some kinds of common broad-band LFNs. Our human study then showed that broad-band LFN with a narrower frequency range more strongly increased cutaneous blood flow than did broad-band LFN with a wider frequency range. Pure-tone LFNs of 70–100 Hz at ≤85 dB(Z), but not pure-tone LFNs exceeding 100 Hz, further increased levels of cutaneous blood flow. Our wavelet-transform spectrum analysis of cutaneous blood flow next revealed that the nitric oxide (NO)-dependent and -independent vascular activities of the vascular endothelium were specifically increased by exposure to pure-tone LFN. Our animal study again indicated that exposure to pure-tone LFN increased cutaneous blood flow in mice with impairments of bilateral inner ears as well as cutaneous blood flow in control mice, suggesting a limited effect of inner ear function on the LFN-mediated increase in cutaneous blood flow. The NO-dependent suppressive effect of pure-tone LFN on cutaneous blood flow was confirmed by inhibition of vascular endothelial activity through intravenous injection of an NO inhibitor in wild-type mice. Taken together, the results of this study demonstrated that the vascular endothelium is a target tissue of LFN and that NO is an effector of the LFN-mediated increase in cutaneous blood flow. Since improvement of peripheral circulation could generally promote human health, short-term exposure to LFN may be beneficial for health. [Display omitted] •A novel effect of low frequency noise (LFN) on microcirculation was determined.•Broad-band LFN (bLFN) exposure increased cutaneous blood flow (cBF) in humans.•Exposure to pure-tone components in bLFN further increased cBF in humans and mice.•The endothelium was identified as a target tissue for short-term exposure to LFN.•Nitric oxide contributed to the increased level of cBF caused by LFN exposure.