Mononuclear cell leukemia in aged Sprague-Dawley rats

A mononuclear cell leukemia in Sprague-Dawley rats is described in which liver, spleen, and lung involvement was a constant feature. The cell was 16 to 25 microns in diameter with round, oval or indented nucleus, and the cytoplasm contained bright red granules. This is the first report of such a leu...

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Bibliographic Details
Published inVeterinary pathology Vol. 20; no. 4; p. 434
Main Authors Abbott, D P, Prentice, D E, Cherry, C P
Format Journal Article
LanguageEnglish
Published United States 01.07.1983
Subjects
Animals
Female
Leukemia - pathology
Leukemia - veterinary
Leukemia, Experimental - pathology
Liver - pathology
Lung - pathology
Male
Monocytes - ultrastructure
Rats
Rats, Inbred Strains
Rats, Inbred WF
Rodent Diseases - pathology
Spleen - pathology
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Summary:A mononuclear cell leukemia in Sprague-Dawley rats is described in which liver, spleen, and lung involvement was a constant feature. The cell was 16 to 25 microns in diameter with round, oval or indented nucleus, and the cytoplasm contained bright red granules. This is the first report of such a leukemia in Sprague-Dawley rats and a comparison with mononuclear cell leukemia in other strains of laboratory rats is made.
ISSN:0300-9858
DOI:10.1177/030098588302000406