Protective Effects and Mechanism of Polysaccharides from Edible Medicinal Plants in Alcoholic Liver Injury: A Review

Alcohol use accounts for a large variety of diseases, among which alcoholic liver injury (ALI) poses a serious threat to human health. In order to overcome the limitations of chemotherapeutic agents, some natural constituents, especially polysaccharides from edible medicinal plants (PEMPs), have bee...

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Published inInternational journal of molecular sciences Vol. 24; no. 22; p. 16530
Main Authors Su, Zhuo-Wen, Yan, Ting-Yu, Feng, Jing, Zhang, Meng-Yuan, Han, Lei, Zhang, Hua-Feng, Xiao, Ying
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2023
Subjects
Adenosine
Alcoholism
Analysis
Apoptosis
Chemotherapy
Cholesterol
Dehydrogenases
Enzymes
Growth factors
Health aspects
Herbal medicine
Kinases
Lipids
Liver
Liver diseases
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Metabolism
Metabolites
Microbiota (Symbiotic organisms)
Oxidative stress
Pathogenesis
Polysaccharides
Protein expression
Proteins
Tumor necrosis factor-TNF
China
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Summary:Alcohol use accounts for a large variety of diseases, among which alcoholic liver injury (ALI) poses a serious threat to human health. In order to overcome the limitations of chemotherapeutic agents, some natural constituents, especially polysaccharides from edible medicinal plants (PEMPs), have been applied for the prevention and treatment of ALI. In this review, the protective effects of PEMPs on acute, subacute, subchronic, and chronic ALI are summarized. The pathogenesis of alcoholic liver injury is analyzed. The structure–activity relationship (SAR) and safety of PEMPs are discussed. In addition, the mechanism underlying the hepatoprotective activity of polysaccharides from edible medicinal plants is explored. PEMPs with hepatoprotective activities mainly belong to the families Orchidaceae, Solanaceae, and Liliaceae. The possible mechanisms of PEMPs include activating enzymes related to alcohol metabolism, attenuating damage from oxidative stress, regulating cytokines, inhibiting the apoptosis of hepatocytes, improving mitochondrial function, and regulating the gut microbiota. Strategies for further research into the practical application of PEMPs for ALI are proposed. Future studies on the mechanism of action of PEMPs will need to focus more on the utilization of multi-omics approaches, such as proteomics, epigenomics, and lipidomics.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242216530