Genetic alterations in mature B- and T-cell lymphomas – a practical guide to WHO-HAEM5

The identification of recurrent genomic alterations in tumour cells has a significant role in the classification of mature B- and T-cell lymphomas. Following the development of new technologies, such as next generation sequencing and the improvement of classical technologies such as conventional and...

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Published inMedizinische Genetik Vol. 36; no. 1; pp. 59 - 73
Main Authors López, Cristina, Fischer, Anja, Rosenwald, Andreas, Siebert, Reiner, Ott, German, Kurz, Katrin S.
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 01.04.2024
Subjects
B- and T-cell lymphomas
chromosomal rearrangements
copy number alterations
MAIN TOPIC Genetic Alterations of Haematolymphoid Tumours
prognostic factors
somatic variants
B- and T-cell lymphomas
prognostic factors
somatic variants
chromosomal rearrangements
copy number alterations
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Summary:The identification of recurrent genomic alterations in tumour cells has a significant role in the classification of mature B- and T-cell lymphomas. Following the development of new technologies, such as next generation sequencing and the improvement of classical technologies such as conventional and molecular cytogenetics, a huge catalogue of genomic alterations in lymphoid neoplasms has been established. These alterations are relevant to refine the taxonomy of the classification of lymphomas, to scrutinize the differential diagnosis within different lymphoma entities and to help assessing the prognosis and clinical management of the patients. Consequently, here we describe the key genetic alterations relevant in mature B- and T-cell lymphomas.
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ISSN:0936-5931
1863-5490
DOI:10.1515/medgen-2024-2005