Plasma From Women with Preeclampsia Has a Low Lipid and Ketone Body Content-A Nuclear Magnetic Resonance Study

• Published in: Hypertension in pregnancy Vol. 26; no. 3; pp. 329 - 342
• Main Authors: Turner, Elizabeth, Brewster, Jennifer A., Simpson, Nigel A. B., Walker, James J., Fisher, Julie
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2007; Taylor & Francis
• Subjects: Case-Control Studies; Female; Humans; Ketone bodies; Ketone Bodies - blood; Lipid peroxidation; Lipids - blood; Magnetic Resonance Spectroscopy; Metabolic profiling; NMR; Oxidative stress; Pre-Eclampsia - blood; Pre-Eclampsia - diagnosis; Preeclampsia; Pregnancy; Principal Component Analysis
• ISSN: 1064-1955; 1525-6065
• DOI: 10.1080/10641950701436073

Objective: Using 1H-nuclear magnetic resonance spectroscopy and chemometrics, we sought to establish the metabolic profile for preeclampsia and to identify biomarkers that would permit a distinction between women with a normal pregnancy and those suffering from preeclampsia. Methods: Plasma samples from 11 normotensive pregnant women and 11 women with preeclampsia were analyzed. Principal component analysis was applied to differentiate between the two groups of patients. Results: Lipid concentrations were found to be significantly lower in the plasma of patients suffering from preeclampsia than those in normotensive pregnant women (p = 0.031). There is also evidence to suggest that ketone body constituents may contribute to the discrimination. Conclusion: 1H-nuclear magnetic resonance-based metabolic profiling can detect patients with preeclampsia.