The evaluation of tactile dysfunction in the hand in type 1 diabetes: a novel method based on haptics

• Published in: Acta diabetologica Vol. 59; no. 8; pp. 1073 - 1082
• Main Authors: Picconi, F., Ryan, C. P., Russo, B., Ciotti, S., Pepe, A., Menduni, M., Lacquaniti, F., Frontoni, S., Moscatelli, A.
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 2022; Springer Nature B.V
• Subjects: Diabetes; Diabetes mellitus (insulin dependent); Diabetic neuropathy; Haptics; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Nerve conduction; Original; Original Article; Diabetic neuropathies; Haptic technology; Vibration; Touch; Hand; Motion perception
• ISSN: 1432-5233; 0940-5429; 1432-5233
• DOI: 10.1007/s00592-022-01903-1

Aims We present an innovative method based on haptics for the evaluation of the sense of touch in the hand, in people affected by type 1 diabetes. Methods Forty individuals affected by diabetes and 20 healthy controls took part in the study; the diabetes group was further divided into two subgroups based on vibration sensitivity in the lower limb. By means of a novel haptic device, tactile sensitivity in the fingertip was measured as the ability of the participants to discriminate slip motion speed. Results Tactile sensitivity was significantly lower in individuals affected by diabetes as compared to controls. Depending on the subgroup, the difference from the controls was equal to 0.11 (95% CI from 0.029 to 0.186) and to 0.267 (95% CI from 0.198 to 0.336). Within the diabetes group, tactile sensitivity correlated with vibration sensitivity in the upper ( p  = 0.001) and lower limb ( p  = 0.003). A significant relationship between nerve conduction parameters and tactile sensitivity was found ( p  = 0.03). Finally, we combined the different predictors (clinical, vibratory and electroneurography data) by using cluster analysis; tactile sensitivity was found to be significantly different between different clusters ( p  = 0.004). Conclusions Early signs of tactile dysfunction in the hand were found in individuals affected by diabetes, even in absence of diabetic neuropathy. The protocol presented in this study is a promising tool for the assessment of tactile dysfunction in the hand in people affected by type 1 diabetes.