Persistent organic pollutants and risk of diabetes and obesity on healthy adults: Results from a cross-sectional study in Spain
Environmental exposure to persistent organic pollutants (POPs) has been reported to be relevant in the population of the Canary Islands (Spain), especially that of organochlorine pesticides. On the other hand, the population of this archipelago presents a high prevalence of type 2 diabetes (T2D), an...
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| Published in | The Science of the total environment Vol. 607-608; pp. 1096 - 1102 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier B.V
31.12.2017
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| Abstract | Environmental exposure to persistent organic pollutants (POPs) has been reported to be relevant in the population of the Canary Islands (Spain), especially that of organochlorine pesticides. On the other hand, the population of this archipelago presents a high prevalence of type 2 diabetes (T2D), and it has been recently reported that environmental chemical contamination could play a role in the development of this disease. We performed a cross-sectional study in a representative sample from this archipelago to evaluate whether serum levels of selected POPs could be considered as risk factors for diabetes in this population. Serum levels of 30 POPs were determined in 429 adults (9.3% with T2D). We found that serum levels of p,p′-DDE (DDE), PCB-153 and PCB-118 were significantly higher among subjects having diabetes than in non-diabetic subjects (p=0.001, p=0.046, and p<0.0001, respectively). We observed a positive correlation between serum p,p′-DDE and glucose levels. Serum p,p′-DDE was identified as a risk factor for diabetes in univariate analysis in the whole series, and it remained as an independent risk factor for diabetes in subjects with serum glucose <126mg/dL (multivariate analysis, Exp(B)=1.283, CI 95% (1.023–1.611), p=0.031). Those normoglycemic subjects that are most exposed to p,p′-DDE (95th percentile: serum p,p′-DDE>5μg/L) seem to be those people at higher risk. Our results showed that p,p′-DDE levels were significantly higher among subjects having diabetes. These findings should be considered by public health Authorities to implement measures devoted to minimize human exposure to pollutants that could be harmful to the population.
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•We explored the role of certain POPs as contributing factor for diabetes.•Levels of p,p′-DDE, were significantly higher in diabetic people.•Serum p,p′-DDE appeared as a risk factor for diabetes in univariate analyses in the whole population.•Serum p,p′-DDE appeared as an independent risk factor for people with glucose <126mg/dL.•p,p′-DDE could be a relevant risk factor for the development of diabetes. |
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| AbstractList | Environmental exposure to persistent organic pollutants (POPs) has been reported to be relevant in the population of the Canary Islands (Spain), especially that of organochlorine pesticides. On the other hand, the population of this archipelago presents a high prevalence of type 2 diabetes (T2D), and it has been recently reported that environmental chemical contamination could play a role in the development of this disease. We performed a cross-sectional study in a representative sample from this archipelago to evaluate whether serum levels of selected POPs could be considered as risk factors for diabetes in this population. Serum levels of 30 POPs were determined in 429 adults (9.3% with T2D). We found that serum levels of p,p'-DDE (DDE), PCB-153 and PCB-118 were significantly higher among subjects having diabetes than in non-diabetic subjects (p=0.001, p=0.046, and p<0.0001, respectively). We observed a positive correlation between serum p,p'-DDE and glucose levels. Serum p,p'-DDE was identified as a risk factor for diabetes in univariate analysis in the whole series, and it remained as an independent risk factor for diabetes in subjects with serum glucose <126mg/dL (multivariate analysis, Exp(B)=1.283, CI 95% (1.023-1.611), p=0.031). Those normoglycemic subjects that are most exposed to p,p'-DDE (95th percentile: serum p,p'-DDE>5μg/L) seem to be those people at higher risk. Our results showed that p,p'-DDE levels were significantly higher among subjects having diabetes. These findings should be considered by public health Authorities to implement measures devoted to minimize human exposure to pollutants that could be harmful to the population.Environmental exposure to persistent organic pollutants (POPs) has been reported to be relevant in the population of the Canary Islands (Spain), especially that of organochlorine pesticides. On the other hand, the population of this archipelago presents a high prevalence of type 2 diabetes (T2D), and it has been recently reported that environmental chemical contamination could play a role in the development of this disease. We performed a cross-sectional study in a representative sample from this archipelago to evaluate whether serum levels of selected POPs could be considered as risk factors for diabetes in this population. Serum levels of 30 POPs were determined in 429 adults (9.3% with T2D). We found that serum levels of p,p'-DDE (DDE), PCB-153 and PCB-118 were significantly higher among subjects having diabetes than in non-diabetic subjects (p=0.001, p=0.046, and p<0.0001, respectively). We observed a positive correlation between serum p,p'-DDE and glucose levels. Serum p,p'-DDE was identified as a risk factor for diabetes in univariate analysis in the whole series, and it remained as an independent risk factor for diabetes in subjects with serum glucose <126mg/dL (multivariate analysis, Exp(B)=1.283, CI 95% (1.023-1.611), p=0.031). Those normoglycemic subjects that are most exposed to p,p'-DDE (95th percentile: serum p,p'-DDE>5μg/L) seem to be those people at higher risk. Our results showed that p,p'-DDE levels were significantly higher among subjects having diabetes. These findings should be considered by public health Authorities to implement measures devoted to minimize human exposure to pollutants that could be harmful to the population. Environmental exposure to persistent organic pollutants (POPs) has been reported to be relevant in the population of the Canary Islands (Spain), especially that of organochlorine pesticides. On the other hand, the population of this archipelago presents a high prevalence of type 2 diabetes (T2D), and it has been recently reported that environmental chemical contamination could play a role in the development of this disease. We performed a cross-sectional study in a representative sample from this archipelago to evaluate whether serum levels of selected POPs could be considered as risk factors for diabetes in this population. Serum levels of 30 POPs were determined in 429 adults (9.3% with T2D). We found that serum levels of p,p′-DDE (DDE), PCB-153 and PCB-118 were significantly higher among subjects having diabetes than in non-diabetic subjects (p=0.001, p=0.046, and p<0.0001, respectively). We observed a positive correlation between serum p,p′-DDE and glucose levels. Serum p,p′-DDE was identified as a risk factor for diabetes in univariate analysis in the whole series, and it remained as an independent risk factor for diabetes in subjects with serum glucose <126mg/dL (multivariate analysis, Exp(B)=1.283, CI 95% (1.023–1.611), p=0.031). Those normoglycemic subjects that are most exposed to p,p′-DDE (95th percentile: serum p,p′-DDE>5μg/L) seem to be those people at higher risk. Our results showed that p,p′-DDE levels were significantly higher among subjects having diabetes. These findings should be considered by public health Authorities to implement measures devoted to minimize human exposure to pollutants that could be harmful to the population. Environmental exposure to persistent organic pollutants (POPs) has been reported to be relevant in the population of the Canary Islands (Spain), especially that of organochlorine pesticides. On the other hand, the population of this archipelago presents a high prevalence of type 2 diabetes (T2D), and it has been recently reported that environmental chemical contamination could play a role in the development of this disease. We performed a cross-sectional study in a representative sample from this archipelago to evaluate whether serum levels of selected POPs could be considered as risk factors for diabetes in this population. Serum levels of 30 POPs were determined in 429 adults (9.3% with T2D). We found that serum levels of p,p′-DDE (DDE), PCB-153 and PCB-118 were significantly higher among subjects having diabetes than in non-diabetic subjects (p=0.001, p=0.046, and p<0.0001, respectively). We observed a positive correlation between serum p,p′-DDE and glucose levels. Serum p,p′-DDE was identified as a risk factor for diabetes in univariate analysis in the whole series, and it remained as an independent risk factor for diabetes in subjects with serum glucose <126mg/dL (multivariate analysis, Exp(B)=1.283, CI 95% (1.023–1.611), p=0.031). Those normoglycemic subjects that are most exposed to p,p′-DDE (95th percentile: serum p,p′-DDE>5μg/L) seem to be those people at higher risk. Our results showed that p,p′-DDE levels were significantly higher among subjects having diabetes. These findings should be considered by public health Authorities to implement measures devoted to minimize human exposure to pollutants that could be harmful to the population. [Display omitted] •We explored the role of certain POPs as contributing factor for diabetes.•Levels of p,p′-DDE, were significantly higher in diabetic people.•Serum p,p′-DDE appeared as a risk factor for diabetes in univariate analyses in the whole population.•Serum p,p′-DDE appeared as an independent risk factor for people with glucose <126mg/dL.•p,p′-DDE could be a relevant risk factor for the development of diabetes. |
| Author | Serra-Majem, Lluis Valerón, Pilar F. Luzardo, Octavio P. Zumbado, Manuel González-Antuña, Ana Camacho, María Boada, Luis D. Henríquez-Hernández, Luis Alberto |
| Author_xml | – sequence: 1 givenname: Luis Alberto surname: Henríquez-Hernández fullname: Henríquez-Hernández, Luis Alberto organization: Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain – sequence: 2 givenname: Octavio P. surname: Luzardo fullname: Luzardo, Octavio P. email: octavio.perez@ulpgc.es organization: Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain – sequence: 3 givenname: Pilar F. surname: Valerón fullname: Valerón, Pilar F. organization: Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain – sequence: 4 givenname: Manuel surname: Zumbado fullname: Zumbado, Manuel organization: Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain – sequence: 5 givenname: Lluis surname: Serra-Majem fullname: Serra-Majem, Lluis organization: Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERObn), Spain – sequence: 6 givenname: María surname: Camacho fullname: Camacho, María organization: Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain – sequence: 7 givenname: Ana surname: González-Antuña fullname: González-Antuña, Ana organization: Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain – sequence: 8 givenname: Luis D. surname: Boada fullname: Boada, Luis D. organization: Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain |
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| Copyright | 2017 Elsevier B.V. Copyright © 2017 Elsevier B.V. All rights reserved. |
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| Keywords | PCB-114 (PubChem CID: 53036) PCB-52 (PubChem CID: 37248) p,p′-DDT (PubChem CID: 3036) γ-Hexachlorocyclohexane/Lindane (PubChem CID: 727) β-Hexachlorocyclohexane (PubChem CID: 727) PCB-118 (PubChem CID: 35823) α-Hexachlorocyclohexane (PubChem CID: 727) PCB-180 (PubChem CID: 37036) p,p′-DDE (PubChem CID: 3035) PCB-169 (PubChem CID: 36231) PCB-167 (PubChem CID: 40479) Canary Islands o,p′-DDD (PubChem CID: 4211) PCB-105 (PubChem CID: 36188) o,p′-DDE (PubChem CID: 246598) PCB-101 (PubChem CID: 37807) PCB-126 (PubChem CID: 63090) Dichloro-diphenyl-trichloroethylene PCB-189 (PubChem CID: 38306) Dieldrin (PubChem CID: 969491) δ-Hexachlorocyclohexane (PubChem CID: 727) Endrin (PubChem CID: 71312306) PCB-77 (PubChem CID: 36187) Persistent organic pollutants p,p′-DDD (PubChem CID: 6294) PCB-156 (PubChem CID: 38019) PCB-153 (PubChem CID: 37034) PCB-202 (PubChem CID: 16495) PCB-81 (PubChem CID: 51043) PCB-123 (PubChem CID: 47650) Aldrin (PubChem CID: 101611446) Polychlorinated biphenyls PCB-138 (PubChem CID: 37035) Diabetes PCB-28 (PubChem CID: 23448) PCB-157 (PubChem CID: 50891) o,p′-DDT (PubChem CID: 13089) Tetrachloro-m-xylene (PubChem CID: 70139) |
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| Title | Persistent organic pollutants and risk of diabetes and obesity on healthy adults: Results from a cross-sectional study in Spain |
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