Design and Rationale of the Intima-Medial Thickness Sub-Study of the PreventIon of CArdiovascular Events in iSchemic Stroke Patients with High Risk of Cerebral hemOrrhage (PICASSO-IMT) Study

• Published in: Journal of stroke and cerebrovascular diseases Vol. 26; no. 9; pp. 1892 - 1898
• Main Authors: Seo, Woo-Keun, Kim, Yong Jae, Lee, Juneyoung, Kwon, Sun U., Kwon, S.U., Lee, J.Y., Kim, Y.J., Seo, W.K., Lee, S.H., Lee, Y.S., Kim, D.E., Lee, J.H., Rha, J.H., Park, K.Y., Heo, S.H., Cho, K.H., Kim, H.Y., Kim, Y.D., Cho, A.H., Baik, J.S., Lee, J.S., Park, J., Park, T.H., Kim, E.G., Koh, I.S., Cha, J.K., Choi, N.C., Kwon, J.H., Sohn, S.I., Lee, J., Hwang, Y.H., Song, H.J., Shin, B.S., Kim, J.T., Lee, S.J., Park, H.Y., Ahn, S.H., Chung, P.W., Kwon, S.B., Sin, D.I., Do, J.K., Lee, S.B., Lee, Y.B., Yoo, B.G., Sung, S.M., Kim, O., Jung, J.M., Lee, K.Y., Jung, Y.H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2017
• Subjects: atherosclerosis; Brain Ischemia - diagnostic imaging; Brain Ischemia - etiology; Brain Ischemia - prevention & control; Cardiovascular Agents - therapeutic use; Carotid Artery Diseases - complications; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - drug therapy; Carotid Artery, Common - diagnostic imaging; Carotid Artery, Common - drug effects; Carotid Intima-Media Thickness; Cerebral Hemorrhage - diagnostic imaging; Cerebral Hemorrhage - etiology; Cerebral Hemorrhage - prevention & control; Clinical Protocols; Double-Blind Method; Humans; Intima-medial thickness; ischemic stroke; Predictive Value of Tests; Probucol - therapeutic use; Prospective Studies; randomized clinical trial; recurrence; Republic of Korea; Research Design; Risk Factors; Stroke - diagnostic imaging; Stroke - etiology; Stroke - prevention & control; Tetrazoles - therapeutic use; Time Factors; Treatment Outcome; recurrence; atherosclerosis; randomized clinical trial; Intima-medial thickness; ischemic stroke
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2017.06.035

Atherosclerosis is one of the main mechanisms of stroke and cardiovascular diseases and is associated with increased risk of recurrent stroke and cardiovascular events. Intima-medial thickness (IMT) is a well-known surrogate marker of atherosclerosis and has been used to predict stroke and cardiovascular events. However, the clinical significance of IMT and IMT change in stroke has not been investigated in well-designed studies. The PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage—Intima-Media Thickness (PICASSO-IMT) sub-study is designed to investigate the effects of cilostazol, probucol, or both on IMT in patients with stroke. PICASSO-IMT is a prospective sub-study of the PICASSO study designed to measure IMT and plaque score at 1, 13, 25, 37, and 49 months after randomization. The primary outcome is the change in mean carotid IMT, which is defined as the mean of the far-wall IMTs of the right and left common carotid arteries, between baseline and 13 months after randomization. PICASSO-IMT will provide the largest IMT data set in a stroke population and will provide valuable information about the clinical significance of IMT in patients with ischemic stroke.