A 356-Kb Sequence of the Subtelomeric Part of the MHC Class I Region

• Published in: DNA sequence Vol. 10; no. 4-5; pp. 263 - 299
• Main Authors: Hampe, Annie, Coriton, Olivier, Andrieux, Nancy, Carn, Gwenaelle, Lepourcelet, MaïNa, Mother, StéPhanie, Dréano, StéPhane, Gatius, Marie Thérèse, Hitte, Christophe, Soriano, Nicolas, Galibert, Francis
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 1999; Taylor & Francis
• Subjects: Animals; bioinformatic; Chromosomes, Artificial, Yeast; Databases, Factual; Expressed Sequence Tags; Genes, MHC Class I; genomic sequence; human; Humans; MHC Class I; Molecular Sequence Data; Polymerase Chain Reaction; repetitive DNA; Repetitive Sequences, Nucleic Acid; sequence analogy; Telomere
• ISSN: 1042-5179; 1029-2365
• DOI: 10.3109/10425179909033955

The subtelomeric part of the MHC Class I region contains 11 of the 21 genes described on chromosome 6 at position 6p21.3. The general organization of those and other genes resident in the region was revealed by determining a 356,376 bp sequence. Potential exons for new genes were identified by computer analysis and a large number of ESTs were selected by testing the sequence by the BLAST algorithm against the Gen-Bank nonredundant and EST databases. Most of the ESTs are clustered in two regions. In contrast, the whole HLA-gene region is crammed with LINE and SINE repeats, fragments of genes and microsatellites, which tends to hinder the identification of new genes.