Extract of Ginkgo Biloba Promotes the Expression of VEGF Following Subarachnoid Hemorrhage in Rats

• Published in: International journal of neuroscience Vol. 119; no. 7; pp. 995 - 1005
• Main Authors: Sun, Bao-Liang, Hu, Dong-Mei, Yuan, Hui, Ye, Wen-Jing, Wang, Xin-Cheng, Xia, Zuo-Li, Zhang, Su-Ming, Wang, Le-Xin
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 2009; Taylor & Francis
• Subjects: Angiogenesis Inducing Agents - pharmacology; Angiogenesis Inducing Agents - therapeutic use; Animals; Brain Ischemia - drug therapy; Brain Ischemia - etiology; cerebral ischemia; Drug Evaluation, Preclinical; Female; Gene Expression Regulation - drug effects; Ginkgo biloba; Ginkgo biloba - chemistry; Male; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rats; Rats, Wistar; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; subarachnoid hemorrhage; Subarachnoid Hemorrhage - complications; Subarachnoid Hemorrhage - drug therapy; Subarachnoid Hemorrhage - genetics; vascular endothelial growth factor; Vascular Endothelial Growth Factor A - biosynthesis; Vascular Endothelial Growth Factor A - genetics
• ISSN: 0020-7454; 1563-5279; 1543-5245
• DOI: 10.1080/00207450902815842

The study aimed to investigate the effect of extract of Ginkgo biloba (EGb) on the expression of vascular endothelial growth factor (VEGF) after subarachnoid hemorrhage (SAH). Wistar rats were divided into non-SAH, SAH, vehicle, EGb1 (low-dose), and EGb2 (high-dose) groups. VEGF mRNA and VEGF protein were measured from brain tissues. The expressions of VEGF mRNA in SAH and vehicle groups were enhanced 24 and 72 hr after the establishment of SAH. Increased VEGF positive cells were found in the brain tissues in SAH and vehicle groups. The expressions of VEGF mRNA and VEGF protein were further increased by the pretreatment of EGb. We concluded that EGb exerts protective effects on secondary cerebral ischemic injury after SAH via the promotion of the expression of VEGF.