Paraspeckles

Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splici...

Full description

Saved in:
Bibliographic Details
Published inCold Spring Harbor perspectives in biology Vol. 2; no. 7; p. a000687
Main Authors Fox, A. H., Lamond, A. I.
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.07.2010
Subjects
Cell Nucleus - ultrastructure
Humans
Microscopy, Fluorescence
Subcellular Fractions - physiology
Online AccessGet full text
ISSN1943-0264
1943-0264
DOI10.1101/cshperspect.a000687

Cover

More Information
Summary:Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a000687