Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium

• Published in: Experimental and molecular pathology Vol. 126; p. 104750
• Main Authors: Neuman, Manuela G., Seitz, Helmut K., Tuma, Pamela L., Osna, Natalia A., Casey, Carol A., Kharbanda, Kusum K., Cohen, Lawrence B., Malnick, Steve D.H., Adhikari, Raghabendra, Mitra, Ramyajit, Dagur, Raghubendra Singh, Ganesan, Murali, Srinivas, Chava, Madan Kumar, Arumugam, New-Aaron, Moses, Poluektova, Larisa, Thomes, Paul G., Rasineni, Karuna, Opris, Mihai, Teschke, Rolf
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.06.2022
• Subjects: Acetylation; Alcoholic liver disease; Ethanol; Human immunodeficiency virus; Humans; Hyaline Bodies, Lipid and protein traffic; Inflammation; Liver; Liver Diseases, Alcoholic - genetics; Nonalcoholic liver disease; Nutrition; Tissue culture; Translational Research, Biomedical; FFA; PLIN; RNA; ADH; Tissue culture; ALT; MDB; αTAT1; HSC; Acetylation; AB; AH; MT; AIDS; HCC; ER; Nonalcoholic liver disease; EV; WIF-β; CCl4; ROS; Human immunodeficiency virus; AZT; SAH; SAM; NADPH; NAFLD; TGF β; CYP 2E; LPS; PHH; 4HNE; 4MP; MEOS; RLW; Nutrition; Inflammation; DEN; AGS; Alcoholic liver disease; NAD; ALDH; NAC; Hyaline Bodies, Lipid and protein traffic; ACT; CCR; HIV; DNA; LD; ALD
• ISSN: 0014-4800; 1096-0945
• DOI: 10.1016/j.yexmp.2022.104750

The present review is based on the research presented at the symposium dedicated to the legacy of the two scientists that made important discoveries in the field of alcohol-induced liver damage: Professors C.S. Lieber and S.W. French. The invited speakers described pharmacological, toxicological and patho-physiological effects of alcohol misuse. Moreover, genetic biomarkers determining adverse drug reactions due to interactions between therapeutics used for chronic or infectious diseases and alcohol exposure were discussed. The researchers presented their work in areas of alcohol-induced impairment in lipid protein trafficking and endocytosis, as well as the role of lipids in the development of fatty liver. The researchers showed that alcohol leads to covalent modifications that promote hepatic dysfunction and injury. We concluded that using new advanced techniques and research ideas leads to important discoveries in science.