Development of a polystyrene-based microplastic model for bioaccumulation and biodistribution study using radiotracing and nuclear analysis method

The investigation of micro or nano plastics behavior in the environment is essential to minimize the hazards of such pollutants on humans. While the conventional method requires sophisticated procedures and a lot of animal subjects, the nuclear technique confers a sensitive, accurate, and real-time...

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Published inMarine pollution bulletin Vol. 201; p. 116283
Main Authors Munir, Miftakul, Subechi, Moch, Nurmanjaya, Ahid, Prasetya, Kukuh Eka, Rindiyantono, Fernanto, Chairuman, Pratama, Chaidir, Yanto, Pujiyanto, Anung, Setiawan, Herlan, Sarwono, Daya Agung, Sarmini, Endang, Fara, Meita Eka, Suseno, Heny
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2024
Subjects
Animals
Bioaccumulation
human serum albumin
Humans
Iodine-131
marine pollution
Microplastics
Nuclear technique
phosphates
Plastics - analysis
Polystyrene sulfonate
polystyrenes
Polystyrenes - analysis
radiolabeling
seawater
Tissue Distribution
Water Pollutants, Chemical - analysis
Zinc-65
Zinc-65
Nuclear technique
Microplastics
Iodine-131
Polystyrene sulfonate
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Summary:The investigation of micro or nano plastics behavior in the environment is essential to minimize the hazards of such pollutants on humans. While the conventional method requires sophisticated procedures and a lot of animal subjects, the nuclear technique confers a sensitive, accurate, and real-time method using radiolabeled micro or nano plastics as a tracer. In this study, polystyrene sulfonate-based microplastic (PSM) was developed with a size of around 3.6 μm, followed by radiolabeling with iodine-131 (131I) or zinc-65 (65Zn) for microplastic radiotracer model. After a stability study in seawater, phosphate buffer saline (PBS), and human serum albumin (HSA) for fifteen days, PSM-131I remained stable (>90 %), except in HSA (50–60 % after day-9), while PSM-65Zn was unstable (<50 %). •Microplastic models can be prepared from styrofoam waste.•Iodine-131 and zinc-65 are used for the radiolabeling of micropolystyrene sulfonate.•Iodine-131 labeled micro polystyrene sulfonate is stable in phosphate buffer saline and seawater.
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ISSN:0025-326X
1879-3363
1879-3363
DOI:10.1016/j.marpolbul.2024.116283