MTHFR C677T Polymorphism is Not Associated with Placental Abruption or Preeclampsia in Finnish Women

• Published in: Hypertension in pregnancy Vol. 25; no. 2; pp. 73 - 80
• Main Authors: Jääskeläinen, Ester, Keski-Nisula, Leea, Toivonen, Sari, Romppanen, Eeva-Liisa, Helisalmi, Seppo, Punnonen, Kari, Heinonen, Seppo
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2006; Taylor & Francis
• Subjects: Abruptio Placentae - genetics; Adult; C677T; Case-Control Studies; Cytosine; Female; Finland; Finnish; Humans; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; MTHFR; Placental abruption; Polymorphism, Single Nucleotide; Pre-Eclampsia - genetics; Preeclampsia; Pregnancy; Thymine; Finland
• ISSN: 1064-1955; 1525-6065
• DOI: 10.1080/10641950600745137

Objective: The aim of our study was to examine genetic variability in the gene encoding methylenetetrahydrofolate reductase (MTHFR) and individual susceptibility to the placental abruption or preeclampsia. Methods: 362 women (133 with preeclampsia, 117 with placental abruption, and 112 healthy controls) were genotyped for C677T polymorphism in the MTHFR gene. Results: Similar genotype distributions were observed in the frequencies of C/C homozygotes (58.6%, 64.1%, and 57.1% for the three groups, respectively) and mutant homozygotes T/T (9.0%, 5.1% and 5.4%). No significant differences were detected in T allele frequencies (25.2%, 20.5%, and 24.1% for the three groups, respectively). Conclusions: MTHFR C677T polymorphism does not have a major role in the development of preeclampsia or placental abruption in the Finnish population.