Transition metal catalyzed asymmetric cyclopropanation via diazo decomposition: Ligand architecture defining stereoselectivity

Asymmetric cyclopropanation of alkenes through diazo decomposition mediated by transition metal complexes is a widely investigated catalytic reaction to obtain cyclopropanes where high enantioselectivity is achieved by optimizing metal-ligand combination. Instead of a chronological listing of develo...

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Bibliographic Details
Published inSynthetic communications Vol. 48; no. 16; pp. 2003 - 2036
Main Authors Roy, Amalesh, Goswami, S. P., Sarkar, Amitabha
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 18.08.2018
Taylor & Francis Ltd
Subjects
Alkenes
Asymmetric cyclopropanation
Catalysis
chiral ligand
Coordination compounds
Decomposition
diazo decomposition
Enantiomers
ligand symmetry
Ligands
Literature reviews
Organic compounds
Stereoselectivity
Substrates
Transition metal compounds
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Summary:Asymmetric cyclopropanation of alkenes through diazo decomposition mediated by transition metal complexes is a widely investigated catalytic reaction to obtain cyclopropanes where high enantioselectivity is achieved by optimizing metal-ligand combination. Instead of a chronological listing of developments, this review illustrates the existing literature data according to the structural types of ligands in catalytic complexes and attempts to correlate substrate structure and selectivity with ligand design.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2018.1471508