Cerebellar medulloblastoma with multiple differentiation in a dog

• Published in: Veterinary pathology Vol. 35; no. 6; pp. 543 - 546
• Main Authors: Steinberg, H. (University of Wisconsin, Madison, WI.), Galbreath, E.J
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.11.1998
• Subjects: Animals; Astrocytes - chemistry; Astrocytes - pathology; Biomarkers, Tumor - analysis; BRAIN; CASE STUDIES; CELL DIFFERENTIATION; Cell Transformation, Neoplastic; Cerebellar Neoplasms - chemistry; Cerebellar Neoplasms - pathology; Cerebellar Neoplasms - veterinary; CEREBRO; CHEMISTRY; CHIEN; CHIMIE; CLINICAL ASPECTS; DIAGNOSIS; DIAGNOSTIC; DIAGNOSTICO; DIFERENCIACION CELULAR; DIFFERENCIATION CELLULAIRE; Dog Diseases - pathology; DOGS; ENCEPHALE; ESTUDIOS DE CASOS PRACTICOS; ETUDE DE CAS; Fatal Outcome; Female; HISTOLOGY; HISTOPATHOLOGIE; HISTOPATHOLOGY; HISTOPATOLOGIA; Immunoenzyme Techniques - veterinary; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIE; IMMUNOLOGY; INMUNOLOGIA; INSPECCION POSTMORTEM; Medulloblastoma - chemistry; Medulloblastoma - pathology; Medulloblastoma - veterinary; NECROPSIE; NEOPLASMAS; NEOPLASME; NEOPLASMS; Neurons - chemistry; Neurons - pathology; PERRO; POSTMORTEM EXAMINATION; QUIMICA; SINTOMAS; SYMPTOME; SYMPTOMS; neuron; immunohistochemistry; medulloblastoma; glia; Canine
• ISSN: 0300-9858; 1544-2217
• DOI: 10.1177/030098589803500611

A 4-year-old female, spayed Border Collie Dog was brought to the Veterinary Medical Teaching Hospital for evaluation of a progressive head tilt and ataxia that were unresponsive to therapy. Neurologic examination localized a right-sided lesion. The owner refused additional diagnostic tests, and necropsy was performed after euthanasia. Gross findings included atrophy of the temporal muscles and a moderately well delineated, 2.5- X 1.5- X 1.0-cm, gray soft-tissue mass compressing the right cerebellar hemisphere and dorsal hindbrain, resulting in massive dilatation of the lateral, third, and fourth ventricles and hydrocephalus. Histologic examination revealed two distinct features: undifferentiated, primitive, polygonal to fusiform cells with typical morphologic characteristics of medulloblastoma and interspersed areas containing myelinated axons and cells with glial and neuronal differentiation. Immunohistochemical examination confirmed the presence of primitive neuroepithelium and cells with glial and neuronal differentiation.