Effect of Copper Deficiency on Metabolism and Mortality in Rats Fed Sucrose or Starch Diets

• Published in: The Journal of nutrition Vol. 113; no. 7; pp. 1335 - 1345
• Main Authors: Fields, Meira, Ferretti, Renato J., Smith, J. Cecil, Reiser, Sheldon
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.07.1983; American Society for Nutritional Sciences
• Subjects: Adipose Tissue - metabolism; Animals; Biological and medical sciences; ceruloplasmin; cholesterol; copper; Copper - deficiency; Dietary Carbohydrates - pharmacology; Glucose - metabolism; heart histopathology; insulin; Insulin - metabolism; Lipid Metabolism; lipogenesis; Liver - pathology; Male; Medical sciences; Metabolic diseases; Metabolism - drug effects; mortality; Myocardium - pathology; Organ Size; Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...); Rats; Rats, Inbred Strains; starch; Starch - pharmacology; sucrose; Sucrose - pharmacology; ceruloplasmin; insulin; mortality; copper; cholesterol; starch; lipogenesis; sucrose; heart histopathology; Animal model; Vertebrata; Mammalia; Rat; Diet; Deficiency; Mortality; Rodentia; Metabolic diseases; Carbohydrate; Copper; Inorganic element
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/113.7.1335

Copper deficiency was induced in rats by feeding sucrose or starch diets deficient in copper. Copper-deprived rats fed either diet exhibited decreased plasma ceruloplasmin concentration and increased plasma cholesterol. Glucose homeostasis and utilization was impaired both in vivo and in vitro. Oral glucose tolerance was impaired, insulin binding decreased, and CO2 formation and lipogenesis from [U-14C]glucose were decreased. Feeding sucrose but not starch diets deficient in copper magnified the copper deficiency and resulted in 60% mortality. Although both deficient diets contained the same concentration of copper, the hepatic copper concentration of rats fed sucrose was reduced nearly threefold compared to rats fed starch. Reduced epididymal fat pad, increased liver weight, reduced blood hemoglobin and a marked hypertrophy of the heart with gross deformities as well as histopathologic changes were noted only in those rats fed the copper-deficient sucrose diet. The biochemical lesions induced by deprivation of copper can be suppressed by feeding diets containing starch or can be magnified by high sucrose intake.