Is decavanadate a specific inositol 1,4,5-trisphosphate receptor antagonist?

We find that decavanadate competitively antagonizes inositol 1,4,5-trisphosphate-induced Ca super(2+) mobilization from permeabilized SH-SY5Y human neuroblastoma cells.

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Bibliographic Details
Published inBiochemical journal Vol. 277 ( Pt 1); no. 1; p. 294
Main Authors Strupish, J, Wojcikiewicz, R J, Challiss, R A, Safrany, S T, Willcocks, A L, Potter, B V, Nahorski, S R
Format Journal Article
LanguageEnglish
Published England 01.07.1991
Subjects
Adrenal Cortex - metabolism
Animals
Calcium Channels
Cell Line
Cerebellum - metabolism
decavanadate
Humans
inositol 1,4,5-trisphosphate
Inositol 1,4,5-Trisphosphate - metabolism
Inositol 1,4,5-Trisphosphate Receptors
Kinetics
Receptors, Cell Surface - drug effects
Receptors, Cell Surface - metabolism
Receptors, Cytoplasmic and Nuclear
Vanadates - pharmacology
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Summary:We find that decavanadate competitively antagonizes inositol 1,4,5-trisphosphate-induced Ca super(2+) mobilization from permeabilized SH-SY5Y human neuroblastoma cells.
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ISSN:0264-6021
1470-8728
DOI:10.1042/bj2770294a