Genetic characteristics of human papillomavirus type 16, 18, 52 and 58 in southern China

• Published in: Genomics (San Diego, Calif.) Vol. 113; no. 6; pp. 3895 - 3906
• Main Authors: Zu, Yuee, Ou, Zhihua, Wu, Dan, Liu, Wei, Liu, Liwen, Wu, Di, Zhao, Yanping, Ren, Peidi, Zhang, Yanqing, Li, Wangsheng, Fu, Shujin, Wen, Yongchun, Cai, Xianchu, Liao, Wenbo, Geng, Chunyu, Zhou, Hongcheng, Wang, Xiaman, Lu, Haorong, Peng, Huanhuan, Liu, Na, Zhu, Shida, Liu, Jiyang, Wang, Dongbo, Li, Junhua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2021
• Subjects: Alphapapillomavirus - genetics; Cervical cancer; China - epidemiology; Chinese female; Complete genome; Female; Genetic Variation; Genotype; HPV; Human papillomavirus 16 - genetics; Humans; Lineage; Mutation; Papillomavirus Infections - complications; Papillomavirus Infections - epidemiology; Phylogeny; Sublineage; China; Chinese female; Lineage; Complete genome; Mutation; Cervical cancer; HPV; Sublineage
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1016/j.ygeno.2021.09.006

Persistent infections of high-risk human papillomaviruses (HPVs) are the leading cause of cervical cancers. We collected cervical exfoliated cell samples from females in Changsha city, Hunan Province and obtained 338 viral genomes of four major HPV types, including HPV 16 (n = 82), 18 (n = 35), 52 (n = 121) and 58 (n = 100). The lineage/sublineage distribution of the four HPVs confirmed previous epidemiological reports, with the predominant prevailing sublineage as A4 (50%), A1 (37%) and A3 (13%) for HPV16, A1 (83%) for HPV18, B2 (86%) for HPV52 and A1 (65%), A3 (19%) and A2 (12%) for HPV58. We also identified two potentially novel HPV18 sublineages, i.e. A6 and A7. Virus mutation analysis further revealed the presence of HPV16 and HPV58 sublineages associated with potentially high oncogenicity. These findings expanded our knowledge of the HPV genetic diversity in China, providing valuable evidence to facilitate HPV DNA screening, vaccine effectiveness evaluation and control strategy development. •A total of 338 full genomes of four high-risk HPV types were obtained from females in Changsha, Hunan province, China.•The predominant sublineages in Changsha included HPV16 A4, A1 and A3, HPV18 A1, HPV52 B2 and HPV58 A1, A3 and A2.•Two potentially novel HPV18 sublineages named A6 and A7 were identified.•Lineage/sublineage conservative mutations were summarized for the four HPV types using global HPV genomes.