Bilateral Infiltrative Disease of the Extraocular Muscles: A Rare Clinical Presentation of Early Stage Chronic Lymphocytic Leukemia

• Published in: Orbit (Amsterdam) Vol. 27; no. 4; pp. 293 - 295
• Main Authors: Ramkissoon, Yashin D., Lee, Richard W. J., Malik, Rizwan, Hsuan, James D., Potts, Mike J.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2008; Taylor & Francis
• Subjects: Aged; Antigens, CD - analysis; B-cell; chrome; Combined Modality Therapy; Functional Laterality; Glucocorticoids - therapeutic use; Humans; Immunophenotyping; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Leukemia, Lymphocytic, Chronic, B-Cell - radiotherapy; leukemic infiltration; Leukemic Infiltration - drug therapy; Leukemic Infiltration - pathology; Leukemic Infiltration - radiotherapy; lymphocytic; Magnetic Resonance Imaging; Male; Methylprednisolone - therapeutic use; neoplasm; Oculomotor Muscles - drug effects; Oculomotor Muscles - pathology; orbit; Orbital Neoplasms - drug therapy; Orbital Neoplasms - pathology; Orbital Neoplasms - radiotherapy; Radiotherapy; staging
• ISSN: 0167-6830; 1744-5108
• DOI: 10.1080/01676830802222878

Orbital involvement in chronic lymphocytic leukemia (CLL) is highly unusual and most commonly involves hemorrhage or soft tissue infiltration in advanced disease. We report a case of rapid onset bilateral orbital muscle infiltration as the presenting feature of early stage CLL. In addition, we demonstrate clinico-pathological correlation with an identical chronic B-cell lymphocytic infiltrate in both orbit and bone marrow, with good response of the orbital disease to local radiotherapy.