Matrix-assisted DOSY

• Published in: Progress in nuclear magnetic resonance spectroscopy Vol. 116; pp. 1 - 18
• Main Author: Day, Iain J.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.02.2020
• Subjects: Chromatography; Diffusion NMR; Micelle; Polymer; Surfactant; Diffusion NMR; Micelle; polySULV; TOCSY; PVP; Surfactant; CTAB; DOSY; DTAB; CHORUS; DQF; PFO; EKC; HPLC; MAGNATE; PROJECT; LC-NMR-MS; SDS; PGSTE; AOT; Polymer; FIDDLE; LC-NMR; PGSE; Chromatography; Eu(fod)3; SEC; MAD; PEG; PARAFAC; GNAT; GPC
• ISSN: 0079-6565; 1873-3301
• DOI: 10.1016/j.pnmrs.2019.09.001

[Display omitted] •Addition of a sample modifier can improve diffusion resolution.•Matrices include chromatographic phases, surfactants and polymers.•Matrix compatibility and tunability is important for effective diffusion resolution.•Choice of matrix for optimal separation remains a topic of active research. The analysis of mixtures by NMR spectroscopy is challenging. Diffusion-ordered NMR spectroscopy enables a pseudo-separation of species based on differences in their translational diffusion coefficients. Under the right circumstances, this is a powerful technique; however, when molecules diffuse at similar rates separation in the diffusion dimension can be poor. In addition, spectral overlap also limits resolution and can make interpretation challenging. Matrix-assisted diffusion NMR seeks to improve resolution in the diffusion dimension by utilising the differential interaction of components in the mixture with an additive to the solvent. Tuning these matrix-analyte interactions allows the diffusion resolution to be optimised. This review presents the background to matrix-assisted diffusion experiments, surveys the wide range of matrices employed, including chromatographic stationary phases, surfactants and polymers, and demonstrates the current state of the art.