Urinary concentrations of bisphenols and parabens and their association with attention, hyperactivity and impulsivity at adolescence

• Published in: Neurotoxicology (Park Forest South) Vol. 95; pp. 66 - 74
• Main Authors: Foreman, Anne B., van Vliet-Ostaptchouk, Jana V., van Faassen, Martijn, Kema, Ido P., Wolffenbuttel, Bruce HR, Sauer, Pieter J.J., Bos, Arend F., Berghuis, Sietske A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2023
• Subjects: ADHD; Adolescent; Benzhydryl Compounds; Bisphenol; Child; Chromatography, Liquid; Female; Humans; Impulsive Behavior; Male; Paraben; Parabens - adverse effects; Parabens - analysis; Sex-specific; Tandem Mass Spectrometry; EtP; LOD; OH-PCB; ADHD; TEA-Ch; BPS; ProP; Paraben; PCB; ButP; MetP; LC-MS/MS; BPA; AVL; Adolescent; BPF; BenP; Bisphenol; BMI; Sex-specific
• ISSN: 0161-813X; 1872-9711
• DOI: 10.1016/j.neuro.2023.01.006

Neurobehavioural disorder diagnoses have been increasing over the last decades, leading to heightened interest in the aetiological factors involved. Endocrine disrupting chemicals, such as parabens and bisphenols, have been suggested as one of those factors. It is unknown whether exposure during adolescence may affect neurobehavioural development. To determine whether urinary concentrations of parabens and bisphenols are associated with attention and concentration in adolescents, in general and sex-specific. We invited 188 adolescents (13–15 years old) for the follow-up birth cohort-study. Concentrations of five parabens and three bisphenols (BPA; BPF; BPS) were measured in morning urine after overnight fasting, using a validated LC-MS/MS method. Attention and concentration were assessed at the clinic with subtests of the Test of Everyday Attention in Children and the Dutch Attention Deficit Hyperactivity Disorder questionnaire (AVL), the latter being filled in by parents. Linear regression analyses were performed, adjusting for urine creatinine concentrations and potential confounding factors. 101 (54%) adolescents participated (46 girls; 55 boys). Urinary paraben concentrations were higher in girls than in boys. Methylparaben was positively associated with attention in girls (p ≤ .05; B= −2.836; 95%CI= −5.175;−.497), ethylparaben negatively with hyperactivity (p ≤ .05; B= −1.864; 95%CI= −3.587;−.141). Butylparaben was associated with more optimal scores on parent reported attention. Propylparaben was negatively associated with scores on sustained auditory attention in girls (p ≤ .10; B=.444; 95%CI= −.009;.896). Bisphenol concentrations were not associated with scores on attention and concentration after adjusting for confounders. In 13–15-year-old Dutch adolescents, urinary concentrations of methylparaben and ethylparaben were associated with better attention and less hyperactivity, whereas a trend toward significance was found between higher urinary propylparaben concentrations and poorer attention. Bisphenol concentrations were not associated with attention and concentration after adjusting for confounders. •Urinary paraben concentrations are higher in 13–15-year-old girls than in boys.•Higher urinary ethylparaben concentrations were associated with less hyperactivity.•Higher urinary methylparaben concentrations were associated with better attention in girls.•Urinary bisphenol concentrations were not associated with attention and concentration.