A Practical Method to Determine Polymer Concentration in Solution by Density

This work describes a method for analyzing polymer concentration in solution using density. The method can be applied to any polymer/solvent combination given certain experimental conditions; however, this study is specific to commercial samples of poly (n-butyl methacrylate) (PBMA) or poly (ethylen...

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Bibliographic Details
Published inInternational journal of polymer analysis & characterization Vol. 14; no. 2; pp. 126 - 139
Main Authors Chisholm, Maureen F., Dwan'isa, Jean-Pierre Latere, Thakur, Sona, Maryanoff, Cynthia A.
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis Group 01.01.2009
Taylor & Francis Ltd
Subjects
Concentration
Density
PBMA
PEVA
Polymer dissolution
Polymer solubility
Polymers
Solvents
Studies
Validity
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Summary:This work describes a method for analyzing polymer concentration in solution using density. The method can be applied to any polymer/solvent combination given certain experimental conditions; however, this study is specific to commercial samples of poly (n-butyl methacrylate) (PBMA) or poly (ethylene-co-vinyl acetate) (PEVA), two polymers of interest to Cordis Corporation. The test method was validated with respect to ICH requirements of linearity, accuracy, precision, range, etc. [ 1 , 2 ] The kinetic dissolution of PBMA or PEVA in tetrahydrofuran (THF) was evaluated as a practical analysis of Cordis process parameters. The results are provided as examples of the test method application.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1023-666X
1563-5341
DOI:10.1080/10236660802586541