Relationship between Serum TSH Level with Obesity and NAFLD in Euthyroid Subjects

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 32; no. 1; pp. 47 - 52
• Main Author: 张皎月 孙晖 陈璐璐 郑涓 胡祥 王素星 陈婷
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.02.2012
• Subjects: Adult; Age Distribution; Aged; Aged, 80 and over; Biomarkers - blood; China; dis-ease; fatty; Fatty Liver - blood; Fatty Liver - complications; Female; function;nonalcoholic; Goiter, Nodular - blood; Goiter, Nodular - complications; hormone;obesity;lipid;thyroid; Humans; liver; Male; Medicine; Medicine & Public Health; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity - blood; Obesity - complications; Reproducibility of Results; Sensitivity and Specificity; Sex Distribution; stimulating; thyroid; Thyrotropin - blood; Young Adult; China; thyroid function; nonalcoholic fatty liver disease; thyroid stimulating hormone; lipid; obesity
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-012-0008-8

To explore the relationship between serum thyroid stimulating hormone (TSH) level and obesity and nonalcoholic fatty liver disease (NAFLD) in euthyroid subjects,1322 subjects were sub-jected to a questionnaire survey and physical examination.Fasting blood samples were collected to test serum TSH,plasma glucose and lipids.Fatty liver was diagnosed by type B ultrasonography.The rela-tionship between serum TSH level and body mass index (BMI),percentage of body fat and NAFLD was analyzed.The results showed that serum TSH level was significantly higher in females than in males at the same group,and it was significantly higher in overweight group than in control group.Levels of body weight,BMI,waist circumference and percentage of body fat were increased in TSH 2.5 group compared to TSH ≤2.5 group in women.However,plasma lipids showed no significant differences.In males all the parameters showed no significant differences between two groups.Serum TSH was sig-nificantly correlated with body weight,BMI,waist circumference and percentage of body fat after ad-justment for age in females.Multiple linear regression analysis revealed that percentage of body fat and BMI contributed significantly to the variance of TSH.Serum TSH level was significantly higher in non-alcoholic fatty liver group than in normal group in females.Multiple logistic regression analysis showed that TSH level was not the independent risk factor of NAFLD.Taken together the data suggest that se-rum TSH in normal range is significantly correlated with BMI and percentage of body fat in females.And the change of TSH level would not influence the prevalence of NAFLD.