Antiviral activity of Colombian Labiatae and Verbenaceae family essential oils and monoterpenes on Human Herpes viruses

• Published in: The Journal of essential oil research Vol. 28; no. 2; pp. 130 - 137
• Main Authors: Brand, Yaneth Miranda, Roa-Linares, Vicky Constanza, Betancur-Galvis, Liliana Amparo, Durán-García, Diego Camilo, Stashenko, Elena
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 03.03.2016
• Subjects: antiviral activity; antiviral properties; essential oil; essential oils; flora; gas chromatography-mass spectrometry; herpes human virus; humans; Hyptis; Labiatae; Lepechinia; monoterpenes; monoterpenoids; Ocimum campechianum; screening; tissue culture; titration; Verbenaceae; viruses
• ISSN: 2163-8152; 1041-2905; 2163-8152
• DOI: 10.1080/10412905.2015.1093556

Colombian flora includes plant families such as Labiatae and Verbenaceae which are employed for treatment of several diseases. In this study, the chemical compositions of essential oils belonging to Labiatae and Verbenaceae families were determined by GC-MS and GC-FID, respectively. The antiviral activity of forty essential oils of these plants and some monoterpenes were evaluated on Human Herpes Viruses types 1 and 2 using end-point titration technique (EPTT). Furthermore, the essential oils and monoterpenes with higher activity reported in the screening were used to evaluate the inhibitory effect on pre-infective stages. The essential oils with the most anti-herpetic activity were those of Labiatae family with Rf values of 1 × 10 ² and 1 × 10 ³ against one Tissue Culture Infectious Dose 50 (TCID ₅₀) of HHV-1 and HHV-2. Moreover Lepechinia salvifolia , Hyptis mutabilis , Lepechinia vulcanicola, Mintostachys mollis and Ocimum campechianum essential oils showed inhibitory activity in the early stages of infection.