Highly accelerated dynamic acquisition of 3D grid‐tagged hyperpolarized‐gas lung images using compressed sensing

• Published in: Magnetic resonance in medicine Vol. 89; no. 6; pp. 2255 - 2263
• Main Authors: Garrison, William J., Qing, Kun, Tafti, Sina, Mugler, John P., Shim, Y. Michael, Mata, Jaime F., Cates, Gordon D., de Lange, Eduard E., Meyer, Craig H., Cai, Jing, Miller, G. Wilson
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2023
• Subjects: Biomechanics; Compressed gas; Compressive properties; Data Compression; Displacement; Exhalation; Humans; Image acquisition; Inhalation; Lobes; Lung - diagnostic imaging; Lungs; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Marking; Respiration; Respiratory function; variable-density MR sampling; pulmonary biomechanics; compressed sensing; tagging MRI; hyperpolarized gas
• ISSN: 0740-3194; 1522-2594; 1522-2594
• DOI: 10.1002/mrm.29595

To develop and test compressed sensing-based multiframe 3D MRI of grid-tagged hyperpolarized gas in the lung. Applying grid-tagging RF pulses to inhaled hyperpolarized gas results in images in which signal intensity is predictably and sparsely distributed. In the present work, this phenomenon was used to produce a sampling pattern in which k-space is undersampled by a factor of approximately seven, yet regions of high k-space energy remain densely sampled. Three healthy subjects received multiframe 3D He tagging MRI using this undersampling method. Images were collected during a single exhalation at eight timepoints spanning the breathing cycle from end-of-inhalation to end-of-exhalation. Grid-tagged images were used to generate 3D displacement maps of the lung during exhalation, and time-resolved maps of principal strains and fractional volume change were generated from these displacement maps using finite-element analysis. Tags remained clearly resolvable for 4-6 timepoints (5-8 s) in each subject. Displacement maps revealed noteworthy temporal and spatial nonlinearities in lung motion during exhalation. Compressive normal strains occurred along all three principal directions but were primarily oriented in the head-foot direction. Fractional volume changes displayed clear bilateral symmetry, but with the lower lobes displaying slightly higher change than the upper lobes in 2 of the 3 subjects. We developed a compressed sensing-based method for multiframe 3D MRI of grid-tagged hyperpolarized gas in the lung during exhalation. This method successfully overcomes previous challenges for 3D dynamic grid-tagging, allowing time-resolved biomechanical readouts of lung function to be generated.