Correlation Between IL-10 Gene Expression and HPV Infection in Cervical Cancer: A Mechanism for Immune Response Escape

• Published in: Cancer investigation Vol. 26; no. 10; pp. 1037 - 1043
• Main Authors: Bermúdez-Morales, Victor H., Gutiérrez, Lourdes X., Alcocer-González, Juan M., Burguete, Ana, Madrid-Marina, Vicente
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2008; Taylor & Francis
• Subjects: Cervical cancer; DNA Primers; DNA, Neoplasm - genetics; DNA, Neoplasm - isolation & purification; Female; Gene Expression Regulation, Neoplastic; HPV; Humans; IL-10; Immunosuppression; Interleukin-10 - genetics; Mexico; Neoplasm Staging; Papillomavirus Infections - complications; Papillomavirus Infections - epidemiology; Papillomavirus Infections - immunology; Prevalence; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; RNA, Neoplasm - genetics; RNA, Neoplasm - isolation & purification; Uterine Cervical Neoplasms - complications; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - immunology; Uterine Cervical Neoplasms - pathology; Mexico
• ISSN: 0735-7907; 1532-4192
• DOI: 10.1080/07357900802112693

The present study was performed to determine IL-10 expression in cervical tissues in Mexican women according to the severity of the malignity and its association with HPV infection. IL-10 expression showed a clear tendency to increase during the different cervical cancer stages: 37% in LGSIL; 62% in HGSIL; and 84% in cancer. However, all the patients that expressed IL-10 were HPV positives; we found an association with HPV 16. These results suggest a clear relationship between IL-10, HPV and the stage of cervical cancer disease; this event could contribute to the immunosuppressive micro-environment in the tumor site.