Modeling Cancers in Drosophila
The basic cellular processes deregulated during carcinogenesis and the vast majority of the genes implicated in cancer appear conserved from humans to flies. This conservation, together with an ever-expanding fly genetic toolbox, has made of Drosophila melanogaster a remarkably profitable model to s...
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Published in | Animal Models of Human Disease Vol. 100; pp. 51 - 82 |
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Main Authors | , , , , |
Format | Book Chapter Journal Article |
Language | English |
Published |
United States
Elsevier Science & Technology
2011
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Subjects | |
Online Access | Get full text |
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Summary: | The basic cellular processes deregulated during carcinogenesis and the vast majority of the genes implicated in cancer appear conserved from humans to flies. This conservation, together with an ever-expanding fly genetic toolbox, has made of
Drosophila melanogaster a remarkably profitable model to study many fundamental aspects of carcinogenesis. In particular,
Drosophila has played a major role in the identification of genes and pathways implicated in cancer and in disclosing novel functional relationships between cancer genes. It has also proved to be a genetically tractable system where to mimic cancer-like situations and characterize the mode of action of human oncogenes. Here, we outline some advances in the study of cancer, both at the basic and more translational levels, which have benefited from research carried out in flies. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
ISBN: | 0123848784 9780123848789 |
ISSN: | 1877-1173 1878-0814 1878-0814 |
DOI: | 10.1016/B978-0-12-384878-9.00002-9 |