ANTI-HIV ACTIVITY OF NOVEL PHOSPHONATE DERIVATIVES OF AZT, d4T, AND ddA

Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was 2′,3′-Dideoxy-2′,3′-didehydrothymidine 5′-isopropylphosphite and among the AZT phosphonate derivatives highest activity was shown by 2′,3′-Dideoxy...

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Bibliographic Details
Published inNucleosides, nucleotides & nucleic acids Vol. 20; no. 4-7; pp. 767 - 769
Main Authors Pokrovsky, A. G., Pronayeva, T. R., Fedyuk, N. V., Shirokova, E. A., Khandazhinskaya, A. L., Tarusova, N. B., Karpenko, I. L., Krayevsky, A. A.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis Group 31.03.2001
Subjects
Anti-HIV Agents - pharmacology
Anti-HIV Agents - toxicity
Cell Line
Cell Survival - drug effects
Dideoxyadenosine - analogs & derivatives
Dideoxynucleosides - pharmacology
Dideoxynucleosides - toxicity
HIV Core Protein p24 - analysis
HIV-1 - drug effects
HIV-1 - physiology
Humans
Immunoenzyme Techniques
Organophosphonates - pharmacology
Organophosphonates - toxicity
Stavudine - analogs & derivatives
Virus Replication - drug effects
Zidovudine - analogs & derivatives
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Summary:Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was 2′,3′-Dideoxy-2′,3′-didehydrothymidine 5′-isopropylphosphite and among the AZT phosphonate derivatives highest activity was shown by 2′,3′-Dideoxy-3′-azidothymidine 5′-cyclohexylphosphite.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-100002426