Ipsilateral weakness caused by ipsilateral stroke: A case series

• Published in: Journal of stroke and cerebrovascular diseases Vol. 32; no. 7; p. 107090
• Main Authors: Kajtazi, Naim I., Bafaquh, Mohammed, Rizvi, Tanvir, Sheikh, Souda El, Ghamdi, Juman Al, Amoudi, Razan Al, Jabbar, Asma Al, Shammari, Kareem Al, Saqqur, Maher, Ghamdi, Saeed Al, Khoja, Waleed, Demchuk, Andrew, Senani, Fahmi Al, Luft, Andreas R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2023
• Subjects: Frailty - complications; Hemorrhagic stroke; Hemorrhagic Stroke - complications; Humans; Hypesthesia - complications; Ipsilateral stroke; Ipsilateral weakness; Ischemic stroke; Magnetic Resonance Imaging; Nervous System Diseases; Stroke - complications; Stroke - diagnostic imaging; Ipsilateral stroke; Ischemic stroke; Ipsilateral weakness; Hemorrhagic stroke
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2023.107090

There are few reported cases of ipsilateral weakness following ischemic or hemorrhagic stroke. In these rare cases, ipsilateral weakness is typically the result of damage to uncrossed components of the corticospinal tract (CST) which were recruited in response to previous CST injury. We report a series of six cases of acute ipsilateral weakness or numbness following a hemorrhagic or ischemic stroke from three medical institutions in Saudi Arabia. Three of these patients presented with right-sided weakness caused by an ipsilateral right hemispheric stroke, while two exhibited left-sided symptoms and one had only left-sided numbness. In all six cases, the ipsilateral corona radiata, internal capsule, basal ganglia, insula, and thalamus were involved. No concomitant opposite hemisphere or brainstem lesion in none of the patients was evident. Two patients had previous strokes affecting the brainstem and left corona radiata, respectively. Complete stroke workup to reveal the cause of stroke was carried out, however no functional MRI was performed. Ischemic or hemorrhagic stroke may indeed result in ipsilateral weakness or numbness, though in very rare cases. We assume that the most likely mechanism of their ipsilateral weakness subsequent to the ipsilateral stroke was a functional reorganization favoring CST pathways within the ipsilateral hemisphere.