Poor oral health and the risk of esophageal squamous cell carcinoma in Malawi

• Published in: International journal of cancer Vol. 154; no. 9; pp. 1587 - 1595
• Main Authors: Kaimila, Bongani, Yano, Yukiko, Mulima, Gift, Chen, Yingxi, Kajombo, Chifundo, Salima, Ande, Khan, Shiraz, Gopal, Satish, Dawsey, Sanford M., Abnet, Christian C.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2024; Wiley Subscription Services, Inc
• Subjects: Case-Control Studies; Demographics; Dental fluorosis; Esophageal cancer; Esophageal carcinoma; Esophageal Neoplasms - epidemiology; Esophageal Neoplasms - etiology; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma - epidemiology; fluorosis; Fluorosis, Dental - epidemiology; Health risks; Humans; Hygiene; Lip; Malawi; Malawi - epidemiology; Mucosa; Oral Health; Oral hygiene; Risk Factors; Squamous cell carcinoma; Toothbrushing; Malawi; fluorosis; oral health; esophageal cancer; Malawi
• ISSN: 0020-7136; 1097-0215; 1097-0215
• DOI: 10.1002/ijc.34829

Esophageal squamous cell carcinoma (ESCC) is the second most common cancer in Malawi. Risk factors for this cancer in Malawi are poorly understood. Poor oral health has previously been linked to increased ESCC risk in other high‐incidence regions, including parts of Eastern and Southern Africa. We assessed the relationship between oral health and ESCC risk in a sex, age and location frequency‐matched case–control study based at two hospitals in Lilongwe, Malawi from 2017 to 2020. Trained interviewers used a structured questionnaire and direct observation to collect data on demographics; behaviors; oral hygiene habits; the sum of decayed, missing or filled teeth (DMFT score); oral mucosa status; lip depigmentation and dental fluorosis via a visual scale. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI), adjusted for known and suspected ESCC risk factors. During the study period, 300 cases and 300 controls were enrolled. Subjects in the highest tertile of DMFT score (≥7) had an increased risk of ESCC with an adjusted OR of 1.96 (95% CI: 1.16–3.36) compared to those with a DMFT score of 0. Severe dental fluorosis was associated with a statistically nonsignificant increased risk of ESCC (adjusted OR = 2.24, 95% CI: 0.97–5.49) compared to individuals with no fluorosis. Associations with oral mucosa status, lip depigmentation and toothbrushing method and frequency were mostly null or uncertain. Poor oral health, indicated by a higher DMFT score, was associated with increased ESCC risk in Malawi. Dental fluorosis is another possible risk factor in this population, but further evaluation is necessary to clarify any effects of fluorosis on ESCC risk. What's new? Malawi has the highest incidence of esophageal cancer in the world, but the etiology of esophageal cancer in this population is poorly understood. In this case–control study, the authors found that, in Malawi, poor oral health indicated by decayed, missing or filled teeth was associated with an increased esophageal cancer risk, consistent with previous findings. Associations with dental fluorosis were not observed as strongly as previously reported in other parts of East Africa. Public health messaging to promote oral health may help reduce the burden of esophageal cancer in high‐risk regions.