Ferroptosis: a novel pathogenesis and therapeutic strategies for Parkinson disease: A review
Parkinson disease (PD) is the second most common neurodegenerative disease, and its incidence is climbing every year, but there is still a lack of effective clinical treatments. In recent years, many studies have shown that ferroptosis plays a key role in the progression of PD. Most importantly, man...
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| Published in | Medicine (Baltimore) Vol. 104; no. 3; p. e41218 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Hagerstown, MD
Lippincott Williams & Wilkins
17.01.2025
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| Abstract | Parkinson disease (PD) is the second most common neurodegenerative disease, and its incidence is climbing every year, but there is still a lack of effective clinical treatments. In recent years, many studies have shown that ferroptosis plays a key role in the progression of PD. Most importantly, many cellular and animal studies and clinical trials have shown that episodes of PD can be alleviated by inhibiting the ferroptosis process, such as utilizing inhibitors, chelating agents, and others. Here, we review the role of ferroptosis, a new form of cell death, in the pathogenesis of PD, and summarize the therapeutic strategies for targeting ferroptosis in PD, hoping to provide new thinking for the study of PD pathogenesis and the development of therapeutic strategies. |
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| AbstractList | Parkinson disease (PD) is the second most common neurodegenerative disease, and its incidence is climbing every year, but there is still a lack of effective clinical treatments. In recent years, many studies have shown that ferroptosis plays a key role in the progression of PD. Most importantly, many cellular and animal studies and clinical trials have shown that episodes of PD can be alleviated by inhibiting the ferroptosis process, such as utilizing inhibitors, chelating agents, and others. Here, we review the role of ferroptosis, a new form of cell death, in the pathogenesis of PD, and summarize the therapeutic strategies for targeting ferroptosis in PD, hoping to provide new thinking for the study of PD pathogenesis and the development of therapeutic strategies. Parkinson disease (PD) is the second most common neurodegenerative disease, and its incidence is climbing every year, but there is still a lack of effective clinical treatments. In recent years, many studies have shown that ferroptosis plays a key role in the progression of PD. Most importantly, many cellular and animal studies and clinical trials have shown that episodes of PD can be alleviated by inhibiting the ferroptosis process, such as utilizing inhibitors, chelating agents, and others. Here, we review the role of ferroptosis, a new form of cell death, in the pathogenesis of PD, and summarize the therapeutic strategies for targeting ferroptosis in PD, hoping to provide new thinking for the study of PD pathogenesis and the development of therapeutic strategies.Parkinson disease (PD) is the second most common neurodegenerative disease, and its incidence is climbing every year, but there is still a lack of effective clinical treatments. In recent years, many studies have shown that ferroptosis plays a key role in the progression of PD. Most importantly, many cellular and animal studies and clinical trials have shown that episodes of PD can be alleviated by inhibiting the ferroptosis process, such as utilizing inhibitors, chelating agents, and others. Here, we review the role of ferroptosis, a new form of cell death, in the pathogenesis of PD, and summarize the therapeutic strategies for targeting ferroptosis in PD, hoping to provide new thinking for the study of PD pathogenesis and the development of therapeutic strategies. |
| Author | Wang, Yaomei Jiao, Di Wang, Kejing Yang, Yang |
| Author_xml | – sequence: 1 givenname: Di orcidid: 0009-0001-7575-9164 surname: Jiao fullname: Jiao, Di organization: School of Medicine, Zhengzhou University of Industrial Technology, Zhengzhou, China – sequence: 2 givenname: Yang surname: Yang fullname: Yang, Yang organization: School of Medicine, Zhengzhou University of Industrial Technology, Zhengzhou, China – sequence: 3 givenname: Kejing surname: Wang fullname: Wang, Kejing organization: School of Medicine, Zhengzhou University of Industrial Technology, Zhengzhou, China – sequence: 4 givenname: Yaomei orcidid: 0009-0000-0150-8752 surname: Wang fullname: Wang, Yaomei email: zlyywangyaomei4132@zzu.edu.cn organization: Department of Hematology, Henan Cancer Hospital, the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39833092$$D View this record in MEDLINE/PubMed |
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| Keywords | Parkinson disease pathogenesis ferroptosis therapeutic strategies |
| Language | English |
| License | http://creativecommons.org/licenses/by/4.0 Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| Notes | Received: 21 August 2024 / Received in final form: 12 December 2024 / Accepted: 17 December 2024 This work was supported partly by the National Natural Science Foundation of China (81900108), the Medical Science and Technology Tackling Program of Henan Province (SBGJ202002024), the Industry-university Cooperative Education program of the Ministry of Education (231005115310726) and the Research project of Henan Federation of Social Sciences (SKL-2023-601). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. Supplemental Digital Content is available for this article. How to cite this article: Jiao D, Yang Y, Wang K, Wang Y. Ferroptosis: a novel pathogenesis and therapeutic strategies for Parkinson disease: A review. Medicine 2025;104:3(e41218). * Correspondence: Yaomei Wang, Department of Hematology, Henan Cancer Hospital, the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China (e-mail: zlyywangyaomei4132@zzu.edu.cn). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
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| Title | Ferroptosis: a novel pathogenesis and therapeutic strategies for Parkinson disease: A review |
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