Ferroptosis: a novel pathogenesis and therapeutic strategies for Parkinson disease: A review

Parkinson disease (PD) is the second most common neurodegenerative disease, and its incidence is climbing every year, but there is still a lack of effective clinical treatments. In recent years, many studies have shown that ferroptosis plays a key role in the progression of PD. Most importantly, man...

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Published inMedicine (Baltimore) Vol. 104; no. 3; p. e41218
Main Authors Jiao, Di, Yang, Yang, Wang, Kejing, Wang, Yaomei
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 17.01.2025
Subjects
Animals
Ferroptosis - drug effects
Ferroptosis - physiology
Humans
Narrative Review
Parkinson Disease - drug therapy
Parkinson Disease - etiology
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson disease
pathogenesis
ferroptosis
therapeutic strategies
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Summary:Parkinson disease (PD) is the second most common neurodegenerative disease, and its incidence is climbing every year, but there is still a lack of effective clinical treatments. In recent years, many studies have shown that ferroptosis plays a key role in the progression of PD. Most importantly, many cellular and animal studies and clinical trials have shown that episodes of PD can be alleviated by inhibiting the ferroptosis process, such as utilizing inhibitors, chelating agents, and others. Here, we review the role of ferroptosis, a new form of cell death, in the pathogenesis of PD, and summarize the therapeutic strategies for targeting ferroptosis in PD, hoping to provide new thinking for the study of PD pathogenesis and the development of therapeutic strategies.
Bibliography:Received: 21 August 2024 / Received in final form: 12 December 2024 / Accepted: 17 December 2024 This work was supported partly by the National Natural Science Foundation of China (81900108), the Medical Science and Technology Tackling Program of Henan Province (SBGJ202002024), the Industry-university Cooperative Education program of the Ministry of Education (231005115310726) and the Research project of Henan Federation of Social Sciences (SKL-2023-601). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. Supplemental Digital Content is available for this article. How to cite this article: Jiao D, Yang Y, Wang K, Wang Y. Ferroptosis: a novel pathogenesis and therapeutic strategies for Parkinson disease: A review. Medicine 2025;104:3(e41218). * Correspondence: Yaomei Wang, Department of Hematology, Henan Cancer Hospital, the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China (e-mail: zlyywangyaomei4132@zzu.edu.cn).
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ISSN:1536-5964
0025-7974
1536-5964
DOI:10.1097/MD.0000000000041218