Pharmacological therapies for the treatment of osteoarthritis

Non-pharmacological interventions are the first-line therapy for osteoarthritis. If non-pharmacological therapy fails, paracetamol (up to 4 g daily) should be added. If paracetamol fails, the patient's risk factors for gastrointestinal and renal disease should be assessed. In patients with gast...

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Bibliographic Details
Published inMedical journal of Australia Vol. 175; no. S3; p. S108
Main Author McColl, G J
Format Journal Article
LanguageEnglish
Published Australia 19.11.2001
Subjects
Acetaminophen - therapeutic use
Analgesics, Non-Narcotic - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis - drug therapy
Celecoxib
Cyclooxygenase Inhibitors - therapeutic use
Humans
Lactones - therapeutic use
Pyrazoles
Sulfonamides - therapeutic use
Sulfones
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Summary:Non-pharmacological interventions are the first-line therapy for osteoarthritis. If non-pharmacological therapy fails, paracetamol (up to 4 g daily) should be added. If paracetamol fails, the patient's risk factors for gastrointestinal and renal disease should be assessed. In patients with gastrointestinal risk factors, a COX-2-specific inhibitor (CSI) would be used in preference to a conventional non-steroidal anti-inflammatory drug (NSAID). In patients with renal risk factors, NSAIDs and CSIs should be used with care. In patients who continue to have problems, other treatments should be considered; these might include intra-articular hyaluronan or depot corticosteroid, analgesia or glucosamine.
ISSN:0025-729X
DOI:10.5694/j.1326-5377.2001.tb143845.x