A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates

• Published in: Scientia pharmaceutica Vol. 79; no. 4; pp. 763 - 777
• Main Authors: Kaminskyy, Danylo, Khyluk, Dmytro, Vasylenko, Olexandr, Zaprutko, Lucjusz, Lesyk, Roman
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 2011; Österreichische Apotheker-Verlagsgesellschaft
• Subjects: 2,3,5-Trisubstituted 4-thiazolidinones; Spiro thiazolidinone isatin conjugates; 2′-[1,3]thiazolidine; Spiro[indole-3; Anticancer activity
• ISSN: 0036-8709; 2218-0532
• DOI: 10.3797/scipharm.1109-14

The synthesis and evaluation of the anticancer activity of 3'-aryl-5'-arylidene-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-diones and spiro[3H-indole-3,2'-thi-azolidine]-2,4'(1H)-dione-3'-alkanoic acid esters were described. The structure of the compounds was determined by (1)H and (13)C NMR and their in vitro anticancer activity was tested in the National Cancer Institute. Among the tested compounds, (5'Z)-5'-(benzylidene)-3'-(4-chlorophenyl)spiro[3H-indole-3,2'-thia-zolidine]-2,4'(1H)-dione (IIa) and (5'Z)-3'-(4-chlorophenyl)-5'-[4-(1-methylethyl)-benzylidene]spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione (IIb) were superior to other related compounds.